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Study-Unit Description
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TITLE Integrated Biomedical Sciences

LEVEL 02 - Years 2, 3 in Modular Undergraduate Course


DEPARTMENT Faculty of Medicine and Surgery

DESCRIPTION This study unit is intended to integrate basic anatomy, physiology, biochemistry and pharmacology using much of the knowledge base already assimilated by the students over the first two years. The topics extend across a number of systems requiring that these be integrated with one another. Each topic will be covered by at least one lecture followed by an interactive tutorial session. The aim of the study unit is to make sure the student is well prepared for the clinical aspects of their course.

Study-unit Aims

To develop students’ abilities to integrate basic biomedical knowledge and skills.

Learning Outcomes

1. Knowledge & Understanding: By the end of the study-unit the student will be able to:

1. Describe the inter-relationships between basic anatomy, physiology and biochemistry and between the different systems of the body - such as the cardiovascular and the respiratory systems.

2. Skills: By the end of the study-unit the student will be able to:

1. Explain the overlapping anatomical and surgical considerations of relations between different organs and tissues and systems in regional conception.
2. Demonstrate on models or human volunteers the basic clinical methods for examining each of the body regions.
3. Identify common abnormalities in radiographs, CT scans and MRIs of various parts of the body
4. Explain the most likely sites of metastatic spread of tumours arising in different parts of the body via the lymphatic, blood and local routes
5. Distinguish the common underlying causes of pain arising from different viscera in terms of anatomy and pathophysiology
6. Predict the motor and sensory consequences of damage or injury to the nerves of the upper and lower limb and their common sites of injury
7. Describe the cellular and embryological basis of different common and less common diseases.
8. Describe the basic functions of the somatic and autonomic nervous systems as exemplified by cranial nerve reflexes.
9. Explain the role of vitamins and minerals in physiological or biochemical processes and to describe the effects of hyper and hypo vitaminoses.
10. Analyse the changes in respiratory physiology on moderate to severe exercise.
11. Discuss the cardiovascular adjustments to exercise and other conditions.
12. Discuss the multifactorial regulation of normal calcium homeostasis in the human body.
13. Outline fuel metabolism in muscle tissue during resting, physical activity and ischaemia and discuss the causes of fatigue after physical activity.
14. Describe adaptive responses by the kidney to loss of functioning nephrons
15. Describe the renal response to decreased renal perfusion
16. Explain the major causes of renal failure
17. Describe the characteristic clinical findings in renal failure
18. Describe the metabolic and respiratory components of acid-base balance and comment on clinical conditions associated with disturbances of the acid-base balance.
19. Focus on Epigenetics including the importance of epigenetics in Cancer and Epigenetic Therapy.
20. Identify factors that may lead patients to abusing prescribing medication.
21. Identify the causes, signs and symptoms of elevated ICP.
22. Explain the conscious state of a person through the Glasgow Coma Scale.
23. Distinguish between the different waveforms in ICP recording (A,B, C-waves).
24. Explain the various strategies for management and treatment of strokes.
25. Recognize how prescribed drugs may be abused by patients.

Main Text/s and any supplementary readings

Main Text for Physiology

Textbook of Medical Physiology
Ed. Guyton & Hall; Saunders
11th Edition, 2006
ISBN: 978-0-7216-0240-0

Main Text for Biochemistry

Mark's Basic Medical Biochemistry: A Clinical Approach.
Michael Lieberman, Allan D. Marks
Third Edition
Walters Kluwer/ Lippincott Williams & Wilkins
ISBN 0-13:978-0-7817-7022-4

Main Texts for Anatomy

Clinical Anatomy by Regions, Richard. S. Snell, 8th Edition
January 2007, Lipincott
ISBN-10: 0-7817-6404-1
ISBN-13: 978-0-7817-6404-9

Clinical Anatomy by Systems, Richard. S. Snell, April 2006
ISBN-10: 0-7817-9164-2
ISBN-13: 978-0-7817-9164-9

Grays Dissection guide for Human Anatomy, Morton, Peterson and Albertine

Imaging Atlas of Human Anatomy, Weir, Jamie and Abrahams, Peter, 3rd Edittion, 2003. ISBN-13: 978-0-7234-3211-1; ISBN-10: 0-7234-3211-2

Young Lowe, Stevens, Heath and Deakin
Wheater's functional Histology. A text and colour atlas. 5th Edition, 2006. ISBN-13: 978-0-443-06850-8 ISBN-10: 0-443-06850-X. Imprint: CHURCHILL LIVINGSTONE

T.W. Sadler
Langman's Medical Embryology Edition: 10th Paperback, 2006
ISBN-10: 0781794854 ; ISBN-13: 9780781794855

Main Text for Pathology

General and Systematic Pathology, JCE Underwood, 4th Edition,
ISBN 0443073341, Churchill Livingstone or
2. Robbins Basic Pathology, V Kumar, A K Abbas, N Fausto, R Mitchell, 8th Edition ISBN1416029737, Saunders

Main Texts for Pharmacology

P. N. Bennett, Morris J. Brown
Clinical Pharmacology: With STUDENTCONSULT Access (Paperback)
10th Edition. Churchill Livingston (2007)
ISBN-10: 0443102449 ISBN-13: 978-0443102448

Humphrey P. Rang, Maureen M. Dale, James M. Ritter BM, Rod Flower
Pharmacology: With STUDENT CONSULT Online Access (Paperback)
6th Edition Churchill Livingstone (2007)
ISBN-10: 0443069115 ISBN-13: 978-0443069116

STUDY-UNIT TYPE Ind Study, Lecture, Project & Group Learning

Assessment Component/s Resit Availability Weighting
Practical Yes 10%
Project (Anatomy) No 10%
Project (Physiology) No 10%
Examination (3 Hours) Yes 70%

LECTURER/S Alexander Aquilina
Jean Calleja Agius
Davis James Camilleri
Simon Camilleri
Mario Caruana
Aaron Casha
Joseph Galea
Alexander Gatt
Richard Muscat
Nikolai Pace
Christian Scerri (Co-ord.)
Pierre Schembri Wismayer
Mario Valentino
Josanne Vassallo
Neville Vassallo
Christian Zammit

The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints.
Units not attracting a sufficient number of registrations may be withdrawn without notice.
It should be noted that all the information in the study-unit description above applies to the academic year 2017/8, if study-unit is available during this academic year, and may be subject to change in subsequent years.

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