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Study-Unit Description
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CODE CPH3011

 
TITLE Pharmacology D

 
LEVEL 03 - Years 2, 3, 4 in Modular Undergraduate Course

 
ECTS CREDITS 4

 
DEPARTMENT Clinical Pharmacology and Therapeutics

 
DESCRIPTION This study-unit will look at the pharmacology and mode of action of drugs used in immunopharmacology and oncology and how drugs affect and are used in endocrine disorders. It will also help students gain an understanding of applied molecular pharmacology.

Study-unit aims

i. To understand the basic pharmacology and mode of action of drugs used in immunopharmacology and oncology
ii. To understand how drugs used in endocrine disorders
iii To gain an understanding of applied molecular pharmacology

Content

By the end of this study-unit, the student will be able to understand:
- Molecular basis of cancer
- Mechanisms of action of chemotherapy and hormonal treatments
- Targeted therapies
- Pharmacokinetics of chemotherapy
- The relationship between toxicity and pharmacology of anti-cancer drugs
- Clinical application of anti-cancer drugs

- Oral and injectable hypoglycaemic agents
- Thyroid hormones
- Male and female sex hormones, contraceptives, HRT
- Vitamin D and parathyroid hormone and Calcitonin
- Drugs affecting the Nitric Oxide pathways
- Experimental approaches to molecular pharmacology
- Receptor signaling, trafficking, dimerization
- Basic molecular cloning, cell culture
- Gene therapy

1. Skills

By the end of this study-unit, the student will be able to:
- Apply basic principles in the treatment and understanding of endocrine disorders
- Apply basic pharmacological principles in the understanding of patient's drug therapy in chemotherapy
- Understand basic approaches to experimental molecular pharmacology
- Adopt a correct understanding of the pharmacology and selection of drugs in these disorders

Main texts:

Recommended
• Humphrey P. Rang HP, Dale MM, Ritter JM, Flower R. Rang & Dale's Pharmacology. Churchill Livingstone. 6th Ed.
• Wecker L, Watts S, Faingold C, Dunaway G, Crespo L. Brody's Human Pharmacology. Mosby. 5th Ed.
• Brooks G (Editor).Gene Therapy: The Use of DNA as a Drug. Pharmaceutical Press
• British National Formulary. Pharmaceutical Press.

Reference/Additional
• Brunton L, Lazo J, Parker K. Goodman & Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill Medical. 11th Ed.
• Waller DG, Renwick AG, Hillier K. Medical Pharmacology and Therapeutics. Saunders. 3rd Ed.

 
RULES/CONDITIONS Before TAKING THIS STUDY-UNIT YOU MUST TAKE CPH2010 AND TAKE CPH2011
In THE SAME YEAR AS TAKING THIS STUDY-UNIT YOU MUST TAKE CPH3010

 
STUDY-UNIT TYPE Lecture and Practical

 
METHOD OF ASSESSMENT
Assessment Component/s Resit Availability Weighting
Examination (2 Hours) Yes 100%

 
LECTURER/S Maria A. Cordina
Anthony Fenech (Co-ord.)
Helen Mc Clay
Vanessa Petroni
Ruth Theuma
Josanne Vassallo

 
The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints.
Units not attracting a sufficient number of registrations may be withdrawn without notice.
It should be noted that all the information in the study-unit description above applies to the academic year 2017/8, if study-unit is available during this academic year, and may be subject to change in subsequent years.
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