| CODE | PHR1026 | ||||||
| TITLE | Introduction to Medicinal Chemistry | ||||||
| UM LEVEL | 01 - Year 1 in Modular Undergraduate Course | ||||||
| MQF LEVEL | Not Applicable | ||||||
| ECTS CREDITS | 2 | ||||||
| DEPARTMENT | Pharmacy | ||||||
| DESCRIPTION | - Drug discovery by design – historical notions - Drug design – schematics - Combinatorial chemistry - Computer modeling techniques - Stereochemical consideration of lead compounds - Principles of QSAR - The contribution of different functional to biological function Study Unit Aims: o to introduce the basic concepts of medicinal chemistry o to lay the foundations that will be made in reference to over the next 3 years of the Medicinal Chemistry Course. o to establish the principles of what makes organic molecules “drug-like” Learning Outcomes: 1. Knowledge & Understanding By the end of this study unit, the student will be able to: o understand principles of rational drug design o differentiate between a molecule that is a good ligand and one that has the potential to become a clinically useful drug o become familiar with Lipinski and Veber’s laws as predictors of bioavailability o understand the impact of biological membranes on in vivo bioavailability 2. Skills By the end of this study unit, the student will be able to: o understand first principles of rational drug design o appreciate that for a novel structure to be clinically viable, both structural and bioavailability considerations must be met. o appreciate the financial constraints under which contemporary drug design operates, and recognize these as being driving forces for standardization of the drug discovery process Main texts: o King FD. Medicinal Chemistry Principles & Practice. Cambridge (UK): The Royal Society of Chemistry. 2002. ISBN 978-0-85404-631-7 o Thomas G. Medicinal Chemistry An Introduction. West Sussex (UK): Wiley. 2004. ISBN 0471489352 o Patrick GL. An Introduction to Medicinal Chemistry. Oxford (UK):Oxford University Press. 2002. ISBN 9780199234479 |
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| STUDY-UNIT TYPE | Lecture and Tutorial | ||||||
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| LECTURER/S | Claire Shoemake |
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2023/4. It may be subject to change in subsequent years. |
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