Prof. Anthony Fenech

Prof. Anthony Fenech

Prof. Anthony Fenech

  B.Pharm.(Hons)(Melit.),M.Phil.,Ph.D.(Nott.)

Associate Professor

Room 113
Dept of Clin Pharm & Therapeutics
University of Malta
Msida
  +356 2340 2580
Professor Fenech graduated with a PhD degree in molecular pharmacology from the University of Nottingham in 2003. His research focussed on the transcriptional regulation of muscarininc receptors in airway disease, and he has maintained airway molecular pharmacology as his main research interest.

In 2012 he was appointed Head of the Department of Clinical Pharmacology and Therapeutics and was later promoted to Associate Professor with effect from January 2016. Professor Fenech is also a current member of the Pharmacogenomics Working Party of the European Medicines Agency and has been appointed to several University committees. He holds collaborative research activities with local and foreign research groups and has supervised and participated in the examination of several Masters and Doctoral dissertations.

Professor Fenech holds a lecturing portfolio that focuses on molecular pharmacology, and contributes to several study-units delivered to different degree courses in the Faculty of Medicine and Surgery, Faculty of Health Sciences and Faculty of Science. He is also the co-ordinator of several study-units delivered by the department.
  • Genetic contributors to drug action
  • Molecular pharmacology with special reference to lung disease

Wain, L.V., Shrine, N., Artigas, M.S., Erzurumluoglu, A.M., Noyvert, B., Bossini-Castillo, L., Obeidat, M., Henry, A.P., Portelli, M.A. & Hall, R.J. 2017, "Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets", Nature genetics, vol. 49, no. 3, pp. 416.

Grech, G., Baldacchino, S., Saliba, C., Grixti, M.P., Gauci, R., Petroni, V., Fenech, A.G. & Scerri, C. 2016, "Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options", Tumor Biology, vol. 37, no. 9, pp. 11691-11700.

Mizzi, C., Dalabira, E., Kumuthini, J., Dzimiri, N., Balogh, I., Başak, N., Böhm, R., Borg, J., Borgiani, P. & Bozina, N. 2016, "A european spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics", PLoS One, vol. 11, no. 9, pp. e0162866.

Fenech, A.G., Sayers, I. & Portelli, M.A. 2015, "Pharmacogenetics of asthma" in Preventive and Predictive Genetics: Towards Personalised Medicine Springer, , pp. 241-274.

Squassina, A., Severino, G., Grech, G., Fenech, A., Borg, J. & Patrinos, G.P. 2012, "Conference Scene: Golden Helix Pharmacogenomics Days: educational activities on pharmacogenomics and personalized medicine", Pharmacogenomics, vol. 13, no. 5, pp. 525-528.

Vidal, C., Borg, J., Fenech, A., Xuereb-anastasi, A. & Scerri, C. 2008, "A silent mutation within protectin (CD59) gene and exon skipping in a family with coeliac disease", European Journal of Human Genetics, vol. 16, no. 243, pp. P05.024.

Duroudier, N.P., Sayers, I., Castagna, C.C., Fenech, A.G., Halapi, E., Swan, C. & Hall, I.P. 2007, "Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes", Cell biochemistry and biophysics, vol. 47, no. 1, pp. 119-129.

Durcan, N., Costello, R.W., Graham McLean, W., Blusztajn, J., Madziar, B., Fenech, A.G., Hall, I.P., Gleich, G.J., McGarvey, L. & Walsh, M.T. 2006, "Eosinophil-mediated cholinergic nerve remodeling", American journal of respiratory cell and molecular biology, vol. 34, no. 6, pp. 775-786.

Duroudier, N.P., Fenech, A.G., Swan, C., Richards, S.A. & Hall, I.P. 2004, "Genomic organisation of the cysteinyl leukotriene receptor 1 (CLTR1) gene", British Journal of Pharmacology, .

Fenech, A.G. 2003, Polymorphic variation and transcriptional regulation of muscarinic receptor genes in human airway cells. , University of Nottingham.

Fenech, A. & Hall, I.P. 2002, "Pharmacogenetics of asthma", British journal of clinical pharmacology, vol. 53, no. 1, pp. 3-15.

Fenech, A.G., Wheatley, A., Ebejer, M.J., Felice, A.E., Ellul-Micallef, R. & Hall, I.P. 2001, "Transmission disequilibrium testing for a muscarinic M2 receptor 3’ untranslated region single nucleotide polymorphism within asthmatic families", American Journal of Respiratory and Critical Care Medicine, vol. 163, pp. A201.

Fenech, A., Ebejer, M., Felice, A., Ellul‐Micallef, R. & Hall, I. 2001, "Mutation screening of the muscarinic M2 and M3 receptor genes in normal and asthmatic subjects", British journal of pharmacology, vol. 133, no. 1, pp. 43-48.

Costello, R.W., Wheatley, A., Fenech, A., Hall, I., Calverley, P. & Ikeda, A. 2000, "Effect of polymorphisms of the M2 muscarinic receptor on vagally-induced bronchoconstriction.", American Journal of Respiratory and Critical Care Medicine, vol. 161, pp. A433.

Fenech, A.G., Wheatley, A.P., Ebejer, M.J., Felice, A.E., Ellul-Micallef, R. & Hall, I.P. 2000, "Mutation screening of the Human M2 and M3 receptor genes in normal and asthmatic individuals", British Journal of Pharmacology, .

Fenech, A., Ebejer, M., Felice, A., Ellul-Micallef, R. & Hall, I. 1999, "Mutation Screening of the Human Muscarinic M2 Receptor in Maltese Asthmatic Patients.", Br.J.Pharmacol., vol. 128, pp. 121P.

  • CPH1903 - Drug Discovery, Development, Regulatory Aspects, Pharmacovigilance
  • CPH2904 - Biological Drugs, Vaccines, Gene Therapy and Pharmacological Biotechnology
  • CPH2909 - Practical Research Training
  • CPH3910 - Research Project
  • MDS1034 - Respiratory System
  • MDS1037 - Organisation of the Body
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