https://www.um.edu.mt/library/oar/handle/123456789/35021 2026-07-31T15:23:05Z 2026-07-31T15:23:05Z Attard, Christopher https://www.um.edu.mt/library/oar/handle/123456789/35781 2018-11-07T02:31:16Z 1992-01-01T00:00:00Z

Title: A pharmaceutical and microbiological analysis of mouthwashes Authors: Attard, Christopher Abstract: Previous evaluation of mouthwashes, have very largely concentrated on determinations on the anti-plaque activity (Axelsson, 1987), their ability to control gingivitis, (Clark et aI, 1987) and the effects of specific chemical agents used to reduce the bacterial count (Hogg, 1987). A pharmaceutical and microbiological analysis of 14 mouthwashes available in Malta were investigated, at St Luke's Hospital and the University of Malta.

1992-01-01T00:00:00Z Vella, John Paul https://www.um.edu.mt/library/oar/handle/123456789/35780 2018-11-07T02:31:04Z 1992-01-01T00:00:00Z

Title: Determination of acetylator phenotype with respect to isoniazid in Malta Authors: Vella, John Paul Abstract: The studies carried out involved isoniazid, an important chemotherapeutic agent in anti-tuberculous treatment. Two main aims were identified, and both were concerned with the existence of fast and slow acetylators (inactivators) of isoniazid. The first aim was the determination of the distribution ratio of fast and slow metabolisers in a sample of Maltese volunteers, this quite possibly being the first time any such attempt was made locally. A secondary design of the first aim was the possible correlation of factors, other than genetic ones, with the acetylator phenotype. The second aim was an attempt at reasserting certain genetic principles with regards to the isoniazid acetylator phenotype, in a Maltese context. These principles were established in 1960 by Evans et al and stated that the isoniazid acetylator phenotype is determined by a single pair of genes located on an autosomal chromosome, with the gene for slow acetylation recessive to that for fast acetylation.

1992-01-01T00:00:00Z Micallef, Marco https://www.um.edu.mt/library/oar/handle/123456789/35779 2018-11-07T02:31:09Z 1992-01-01T00:00:00Z

Title: Comparative bioavailability studies of rifampicin Authors: Micallef, Marco Abstract: The present study was undertaken to compare in a cross-over design in both males and females, the bioavaiIability of rifampicin, when given in a combined formulation with isoniazid, between an established standard product and a locally produced generic product.

1992-01-01T00:00:00Z Cilia, Mark https://www.um.edu.mt/library/oar/handle/123456789/35778 2018-11-07T02:30:59Z 1992-01-01T00:00:00Z

Title: Polarography in drug and pharmaceutical analysis Authors: Cilia, Mark Abstract: Electroanalysis is the separation and determination of chemicals by electrolysis. Voltammetry is a term used to describe all electroanalytical techniques, which involve the application of an external potential on the system and utilize the current-potential relationship arising at a polarizable microelectrode to calculate the concentration of the electroactive species. When the working electrode is a mercury electrode, the technique is called polarography. The purpose of this work is to illustrate the applicability of these techniques, especially polarography in pharmacy. This is because the past decase has revealed a remarkable and renewed interest in the application of electroanalytical techniques to the analysis of drugs and pharmaceuticals.

1992-01-01T00:00:00Z