https://www.um.edu.mt/library/oar/handle/123456789/165 2026-04-12T17:20:45Z https://www.um.edu.mt/library/oar/handle/123456789/837 Title: A survey of chromosome anomalies in Malta Authors: Cuschieri, Alfred; Gauci, Sandra Abstract: 433 individuals referred for chromosome analysis between 1983 and 1987 were included in the survey. Among individuals with dysmorphic features or congenital anomalies 42% of babies referred in the neonatal period and 12 to 30% of individuals in older age groups had a chromosome abnormality. Chromosome abnormalities were also found in 10 or 11% of boys or girls with problems of pubertal development, in 14% of azoospermic or severely oligospermic men, in 8.3% of couples with repeated foetal loss and in 5% of couples with malformed children. Whereas most cases of autosomal aneuploidies were diagnosed, a large proportion of sex chromosome anomalies, particularly in males, remained undetected presumably because of under-referral in the pubertal period. The prevalence of chromosome anomalies in Malta was 2.20 per 1,000 births between 1984 and 1987. The incidence of Down Syndrome showed great annual fluctuation with a mean of 1.88 per 1,000 births of which 61% occurred in mothers over 35 years of age. The lowest occurrence risk for trisomy 21 appears to be in the 25 to 34 years maternal age group. 1989-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/834 Title: Supraclavicular node metastasis presenting with internal jugular vein thrombosis Authors: Brincat, Stephen Abstract: A case of internal jugular vein thrombosis secondary to compression by a metastasis in Virchow’s node and the investigations leading to the diagnosis is described. Internal jugular vein thrombosis was not an uncommon complication of fulminant sepsis in the head and neck in the pre-antibiotic era. The commonest causes are now iatrogenic usually secondary to central venous catheterisation or related to intravenous drug abuse. Thrombosis commonly complicates superior vena caval obstruction secondary to malignancy in the chest but isolated internal jugular vein thrombosis is rare and usually secondary to obvious tumour in the neck. Infection related to head and neck malignant disease may also cause venous thrombosis. 1989-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/700 Title: A prescriptions list of 1546 Authors: Fiorini, Stanley Abstract: A prescriptions list for Santo Spirito patients dated 1546, the earliest of its nature found to date, is discussed. Light is thrown on the activities of the hospital, its medical staff, the patients, and the state of the art of medicine in Malta at the time. The document is transcribed in toto. 1989-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/677 Title: The management and treatment of malaria Authors: Gilles, Herbert M. Abstract: Falciparum malaria can create severe complications. Antimalarial drugs such as quinine or chloroquine help in the treatment and management to these complications. The use of chemoprophylaxis is a must for persons travelling abroad to countries subject to malaria, but one must not assume that chemoprophylaxis, even though taken regularly will protect against malaria. 1989-01-01T00:00:00Z