https://www.um.edu.mt/library/oar/handle/123456789/815 2026-04-27T00:54:47Z https://www.um.edu.mt/library/oar/handle/123456789/145906 Title: Smoking and fibrinogen levels modify the risk of Ml due to FXIII V34L : results from the MAMI study Authors: Debattista, J.; Attard, Ritienne; Tabone, C.; Lisman, T.; Cassar, Karen; Doggen, C. J. M.; Bezzina Wettinger, Stephanie; Farrugia, Rosienne Abstract: Background: Coagulation factor XIII (FXIII), after activation by thrombin cleavage in the final step of the coagulation cascade, participates in cross-linking fibrin to form a stable clot. The Leu34 form of the common FXIII V34L polymorphism (rs5985) accelerates the rate by which thrombin activates FXIII during coagulation. 2017-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/145888 Title: Monocyte response to activated platelets : a transcriptional study Authors: Farrugia, Rosienne; Gusnanto, A.; Ellis, P.; Langford, C. F.; Goodall, A. H.; Watkins, N. A.; Ouwehand, W. H. Abstract: Introduction: Plaque rupture exposes platelets to collagen resulting in their activation via the collagen-GPVI/FcRgamma signalling cascade. This signal is communicated to monocytes via two routes; directly by cell-cell contact, or indirectly by a wide spectrum of soluble factors in the platelet secretome. We used whole-genome expression arrays to define the changes in the monocyte transcriptome in response to CRP-18 (collagen-related peptide), a GPVI specific ligand, and contrasted this with the changes that occur upon activation by LPS (lipopolysaccharide) via the CD14/TLR4 signalling cascade. 2007-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/145828 Title: Soluble P-selectin levels are higher in patients with NSTEMI vs STEMI Authors: Agius, C.; Attard, Ritienne; Dingli, Philip; Lisman, T.; Cassar, Karen; Doggen, C. J. M.; Bezzina Wettinger, Stephanie; Farrugia, Rosienne Abstract: P-selectin is stored in the α-granules of platelets and the Weibel-Palade bodies of endothelial cells. Upon activation, it is re distributed to the plasma membrane where it participates in binding to its receptor, P-selectin glycoprotein ligand-1, present on the surface of activated leukocytes. Soluble P-selectin (sP-sel) is a cleaved form detected in plasma and is a marker of platelet activation and endothelial dysfunction. 2017-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/145825 Title: Tetrahydrobiopterin deficiencies in the Maltese population Authors: Farrugia, Rosienne; Naudi, R.; Attard Montalto, S.; Parascandolo, Raymond; Scerri, Christian A.; Bartolo, C.; Felice, A. E. Abstract: A higher than usual frequency of hyperphenylalaninaemia due to tetrahydrobiopterin (BH4) deficiencies, specifically Dihydropteridine Reductase (DHPR) deficiency, is present in the Maltese population. Classical Phenylketonuria due to Phenylalanine Hydroxylase deficiency has not been identified to date. 2002-01-01T00:00:00Z