https://www.um.edu.mt/library/oar/handle/123456789/695 Mon, 13 Apr 2026 06:11:43 GMT 2026-04-13T06:11:43Z https://www.um.edu.mt/library/oar/handle/123456789/143649 Title: Economic burden of poor maternal perinatal mental health : a systematic review Authors: Lynn, Fiona; Bolbocean, Corneliu; Tecirli, Gülcan; Shigdel, Rajesh; Çelik, Yusuf; Çakmak Barsbay, Mehtap; Caparros-Gonzalez, Rafael; van den Akker-van Marle, M. Elske; Sakilah Adnani, Qorinah Estiningtyas; Delimeta, Inesa; Calleja, Neville Abstract: Background Approximately one in five individuals experience poor perinatal mental health, defined as a mental health problem occurring between conception and up to one year after birth. What is unclear is the economic burden of poor perinatal mental health. Wed, 01 Jan 2025 00:00:00 GMT https://www.um.edu.mt/library/oar/handle/123456789/143649 2025-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/143637 Title: Incidence and survival of rare female genital tract cancers in Europe : the EUROCARE-6 study Authors: Gatta, Gemma; Calleja-Agius, Jean; Sandrucci, Sergio; Bennet, Damien; Azzopardi, M. J.; Capocaccia, Riccardo; Hackl, M.; Van Eycken, E.; Valerianova, Z.; Sekerija, M.; Gregoriou, I.; Dusek, L.; Krejici, D.; Storm, H.; Magi, M.; Innos, K.; Pitkaniemi, J.; Velten, M.; Troussard, X.; Bouvier, A. M.; Jooste, V.; Vigneron, N.; Launoy, G.; Dabakuyo Yonli, S.; Maynadie, M.; Guilloteau, A.; Woronoff, A. S.; Nousbaum, J. B.; Coureau, G.; Monnereau, A.; Baldi, I.; Hammas, K.; Tretarre, B.; Colonna, M.; Plouvier, S.; D′Almeida, T.; Molinie, F.; Cowppli-Bony, A.; Bara, S.; Debreuve, A.; Defossez, G.; Lapotre-Ledoux, B.; Lamy, S.; Daubisse-Marliac, L.; Luttmann, S.; Eberle, A.; Stabenow, R.; Nennecke, A.; Peters, F.; Kieschke, J.; Zeissig, S.; Holleczek, B.; Katalinic, A.; Birgisson, H.; Murray, D.; Mazzoleni, G.; Vittadello, F.; Cuccaro, F.; Galasso, R.; Sampietro, G.; Rosso, S.; Gasparotti, C.; Maifredi, G.; Ferrante, M.; Ragusa, R.; Sutera Sardo, A.; Gambino, M. L.; Lanzoni, M.; Ballotari, P.; Giacomazzi, E.; Ferretti, S.; Caldarella, A.; Manneschi, G.; Gatta, G.; Sant, M.; Baili, P.; Berrino, F.; Botta, L.; Trama, A.; Lillini, R.; Bernasconi, A.; Bonfarnuzzo, S.; Vener, C.; Didone, F.; Lasalvia, P.; Buratti, L.; Tagliabue, G.; Dal Maso, L.; Giudici, F.; Capocaccia, R.; De Angelis, R.; Demuru, E.; Cerza, F.; Di Mari, F.; Di Benedetto, C.; Rossi, S.; Santaquilani, M.; Venanzi, S.; Tallon, M.; Boni, L.; Iacovacci, S.; Benfatto, L.; Russo, A. G.; Gervasi, F.; Spagnoli, G.; Cavalieri d′Oro, L.; Fusco, M.; Pinna, P.; Mazzucco, W.; Michiara, M.; Chiaranda, G.; Cascone, G.; Rollo, C. P.; Mangone, L.; Falcini, F.; Cavallo, R.; Piras, D.; Madeddu, A.; Bella, F.; Fanetti, A. C.; Minerba, S.; Candela, G.; Scuderi, T.; Mantovani, W.; Gentilini, M. A.; Stracci, F.; Zorzi, M.; Guzzinati, S.; Ferrarini, N.; Liepina, E.; Smailyte, G.; Azzopardi, M.; Calleja, Neville; Johannesen, T. B.; Didkowska, J.; Wojciechowska, U.; Bielska-Lasota, M.; Bento, M. J.; Silva, P.; Lourenço, A.; Mayer, A.; Safaei Diba, C.; Zadnik, V.; T. Zagar, T.; Ruiz Armengol, P.; Lopez de Munain, A.; DeLa-Cruz, M.; Garrido, M.; Vizcaino, A.; Marcos-Gragera, R.; Sanvisens, A.; Sanchez, M. J.; Redondo-Sanchez, D.; Chirlaque Lopez, M. D.; Sanchez-Gil, A.; Guevara, M.; Ardanaz, E.; Galceran, J.; Carulla, M.; Bergeron, Y.; Flahault, A.; Schaffar, R.; Von Moos, R.; Mohsen Mousavi, S.; Blum, M.; Bordoni, A.; Visser, O.; Stevens, S.; Broggio, J.; Bennett, D.; Gavin, A.; Morrison, D.; Huws, D. W.; Smits, S. Abstract: Cancers of female genital tract (FGTC) account in Europe for 14 % of all female malignancies, and many of them are rare. FGTC epidemiological indicators are usually reported by anatomical site, but they are a heterogeneous group of diseases in terms of morphological characteristics and clinical management. We show incidence and survival population-based estimates and time trends in the European population for FGTC, defined combining topography and morphology codes. We analyzed data of females aged 15 years or more diagnosed with 25 FGTC of which 23 rare. Data were provided by 100 European population-based cancer registries to the EUROCARE-6 project. Incidence was estimated for the period of diagnosis 2001–2013 in terms of both crude and age-adjusted rates. Observed and relative survival was estimated with the complete approach for the period of diagnosis 2008–2013 and with the period approach for trends, considering years of follow-up from 2001 to 2014. Over a total of 793,715 considered diagnoses of FGTC, 279,667 were classified as rare entities. Their crude incidence rate per 100,000 largely varied from almost zero for adenoid cystic carcinoma of corpus uteri to 5.9 for squamous cell carcinoma of cervix uteri. During the period 2001–13, a significant increment was reported for clear cell adenocarcinoma, Mullerian mixed tumor and serous/papillary carcinoma of corpus uteri, for the Mullerian mixed tumor, adenocarcinoma of fallopian tube, and primary peritoneal serous/papillary carcinoma, and malignant/immature teratoma of ovary. Incidence rates significantly reduced for squamous cell carcinoma of cervix uteri, mucinous adenocarcinoma and sex cord tumor of ovary. Five-year relative survival was >84 % for all the non-epithelial tumors of ovary and for choriocarcinoma of placenta. Survival under 40 % was estimated for Mullerian mixed tumors and undifferentiated carcinomas of all the considered sites. Major survival improvements were observed for placenta choriocarcinoma, sex cord tumor, malignant/immature teratoma and mucinous adenocarcinoma of ovary, in adenocarcinoma of fallopian tube and in serous/papillary carcinoma of corpus uteri. Relative survival significantly reduced in squamous cell carcinoma of corpus uteri. The increasing incidence and survival of many rare FGTC can be in part attributed to better diagnostic ability and to a better organisation of care of patients with rare tumors. The epidemiological indicators here provided can be taken as a starting point to evaluate the effectiveness of the future activities of the European Rare Cancers Networks. Wed, 01 Jan 2025 00:00:00 GMT https://www.um.edu.mt/library/oar/handle/123456789/143637 2025-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/143635 Title: Excess mortality in Europe estimated by EuroMOMO during the COVID-19 pandemic and previous influenza seasons Authors: Nørgaard, Sarah K.; Nielsen, Jens; Schjørring, Christel B.; Kalnæs, Albert S.; Richter, Lukas; Chalupka, Alena; Braeye, Toon; Nganda Mekogo, Serge; Athanasiadou, Maria; Lytras, Theodore; Denissov, Gleb; Luomala, Oskari; Pontais, Isabelle; Zacher, Benedikt; an der Heiden, Matthias; Mellou, Kassiani; Panagoulias, Ioannis; Paldy, Anna; Malnasi, Tibor; Kelly, Eva; Rotem, Naama; de’Donato, Francesca K.; Di Blasi, Chiara; Mossong, Joël; Vergison, Anne; England, Kathleen; Calleja, Neville; van Asten, Liselotte; van de Kassteele, Jan; Madsen, Christian; Silva, Susana; Rodrigues, Ana Paula; Kranjec, Natalija; León-Gómez, Inmaculada; Gomez-Barroso, Diana; Galanis, Ilias; Farah, Ahmed; Weitkunat, Rolf; Andrews, Nick; Clare, Tom; Bucholc, Magda; Bradley, Declan T.; William, Naoma; Hamilton, Mark; Jorgensen, Pernille; Pebody, Richard G.; Bundle, Nick; Søborg, Bolette; Krause, Tyra G.; Mølbak, Kåre; Vestergaard, Lasse S. Abstract: Important questions remain regarding differences in geographical and age-specific mortality patterns as the COVID-19 pandemic evolved in consecutive waves, and how COVID-19 mortality compares to seasonal influenza. In a pandemic situation, excess all-cause mortality provides a more complete and robust measure than cause-specific mortality. Data submitted by 26 countries participating in the European Mortality Monitoring (EuroMOMO) network between 2020 and 2023 was analysed to quantify excess all-cause mortality during the COVID-19 pandemic. Excess mortality from this period was compared to previous influenza seasons from 2014 to 2019. Pooled estimates of excess mortality showed four main waves during the COVID-19 pandemic period, most markedly in people aged 65 years and above, with timing and magnitude that varied between countries. Here we show that prior to implementation of control measures and COVID-19 vaccination, excess mortality greatly exceeded typical seasonal influenza mortality, but later during the pandemic was at levels comparable to influenza. Thu, 01 Jan 2026 00:00:00 GMT https://www.um.edu.mt/library/oar/handle/123456789/143635 2026-01-01T00:00:00Z https://www.um.edu.mt/library/oar/handle/123456789/143634 Title: Prognosis of breast cancer in European female adolescents and young adults (AYAs) : EUROCARE-6 retrospective cohort results Authors: Bernasconi, Alice; Toss, Angela; Zattarin, Emma; Mousavi, Seyed Mohsen; Blum, Marcel; Kuehni, Claudia E.; Katalinic, Alexander; Trallero, Jan; Rapiti, Elisabetta; Dal Maso, Luigino; Botta, Laura; Rossi, Silvia; Peccatori, Fedro; Trama, Annalisa; Van Eycken, E.; Van Damme, N.; Valerianova, Z.; Sekerija, M.; Gregoriou, I.; Demetriou, A.; Dusek, L.; Krejici, D.; Storm, H.; Magi, M.; Innos, K.; Pitkaniemi, J.; Velten, M.; Troussard, X.; Bouvier, A. M.; Vigneron, N.; Launoy, G.; Dabakuyo Yonli, S.; Maynadie, M.; Woronoff, A. S.; Nousbaum, J. B.; Coureau, G.; Monnereau, A.; Baldi, I.; Hammas, K.; Tretarre, B.; Colonna, M.; Plouvier, S.; D'Almeida, T.; Molinie, F.; Cowppli-Bony, A.; Bara, S.; Debreuve, A.; Defossez, G.; Lapotre-Ledoux, B.; Daubisse-Marliac, L.; Lamy, S.; Luttmann, S.; Eberle, A.; Stabenow, R.; Nennecke, A.; Peters, F.; Kieschke, J.; Zeissig, S.; Holleczek, B.; Katalinic, A.; Birgisson, H.; Murray, D.; Mazzoleni, G.; Vittadello, F.; Cuccaro, F.; Galasso, R.; Sampietro, G.; Rosso, S.; Gasparotti, C.; Maifredi, G.; Ferrante, M.; Ragusa, R.; Sutera Sardo, A.; Gambino, M. L.; Lanzoni, M.; Ballotari, P.; Giacomazzi, E.; Ferretti, S.; Caldarella, A.; Manneschi, G.; Gatta, G.; Sant, M.; Baili, P.; Berrino, F.; Botta, L.; Trama, A.; Lillini, R.; Bernasconi, A.; Bonfarnuzzo, S.; Vener, C.; Didone, F.; Lasalvia, P.; Buratti, L.; Tagliabue, G.; Giudici, F.; Dal Maso, L.; Capocaccia, R.; De Angelis, R.; Demuru, E.; Cerza, F.; Di Mari, F.; Di Benedetto, C.; Rossi, S.; Santaquilani, M.; Venanzi, S.; Tallon, M.; Boni, L.; Iacovacci, S.; Genova, C.; Russo, A. G.; Gervasi, F.; Spagnoli, G.; Cavalieri d'Oro, L.; Fusco, M.; Vitale, M. F.; Pinna, P.; Mazzucco, W.; Michiara, M.; Chiaranda, G.; Cascone, G.; Rollo, C. P.; Mangone, L.; Falcini, F.; Cavallo, R.; Piras, D.; Madeddu, A.; Bella, F.; Fanetti, A. C.; Minerba, S.; Candela, G.; Scuderi, T.; Mantovani, W.; Gentilini, M. A.; Stracci, F.; Zorzi, M.; Guzzinati, S.; Ferrarini, N.; Liepina, E.; Smailyte, G.; Azzopardi, M.; Calleja, Neville; Johannesen, T. B.; Didkowska, J.; Wojciechowska, U.; Bielska-Lasota, M.; Pais, A.; Bento, M. J.; Calisto, R.; Lourenço, A.; Mayer, A.; Safaei Diba, C.; Zadnik, V.; Zagar, T.; Ruiz Armengol, P.; Lopez de Munain, A.; De-La-Cruz, M.; Garrido, M.; Vizcaino, A.; Marcos-Gragera, R.; Sanvisens, A.; Sanchez, M. J.; Redondo-Sanchez, D.; Chirlaque Lopez, M. D.; Sanchez-Gil, A.; Guevara, M.; Ardanaz, E.; Galceran, J.; Carulla, M.; Bergeron, Y.; Rapiti, E.; Schaffar, R.; Von Moos, R.; Mohsen Mousavi, S.; Blum, M.; Bordoni, A.; Visser, O.; Stevens, S.; Broggio, J.; Bennett, D.; Gavin, A.; Morrison, D.; Huws, D. W.; Smits, S.; Siesling, S. Abstract: Background: Breast cancer (BC) is the most common malignancy in AYA (15–39 years) females and is more aggressive than in adult women (40–69 years). However, an updated overview on BC in AYAs and how it differs from BC in adult women is lacking. Methods: We used data from the EUROCARE-6 study to calculate incidence rates (IRs) of BC in AYA and adult women over the period 2001–2013 in Europe. We estimated 5-year and 10-year relative survival (RS) using period analysis. Stage at diagnosis distribution and conditional RS (CS) were used to investigate survival differences. We also reported cumulative incidence of multiple primary neoplasms (MPNs) in AYAs. Results: The IR of BC in Europe was ~18 per 100,000 in AYA females and more than ten-fold higher in adult women. Most BC cases were diagnosed at Stages I-II (74 % in AYAs vs 77 % in adults). Overall, AYAs had lower 5- year RS than adult women (85.0 % vs 89.5 %, respectively); the survival gap slightly decreased in CS. AYAs had worse survival than adult women for early stage and Stage III but better RS for Stage IV (5-year RS 31.5 % vs. 26.3 %). Cumulative incidence of all MPNs in AYAs was ~6 % at 14 years from BC diagnosis. Conclusions: Our findings support the more aggressive behavior of BC in AYAs. The high proportion of early stage at diagnosis is reassuring considering that organized BC screening is not available for AYAs in Europe. Conversely, the incidence of MPNs in AYAs is relevant and might deserve a revision of follow-up strategies. Wed, 01 Jan 2025 00:00:00 GMT https://www.um.edu.mt/library/oar/handle/123456789/143634 2025-01-01T00:00:00Z