Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBrands, Xanthe-
dc.contributor.authorUhel, Fabrice-
dc.contributor.authorVught, Lonneke A. van-
dc.contributor.authorWiewel, Maryse A.-
dc.contributor.authorHoogendijk, Arie J.-
dc.contributor.authorLutter, René-
dc.contributor.authorSchultz, Marcus J.-
dc.contributor.authorScicluna, Brendon P.-
dc.contributor.authorPoll, Tom van der-
dc.identifier.citationBrands, X., Uhel, F., van Vught, L. A., Wiewel, M. A., Hoogendijk, A. J., Lutter, R., ... & van der Poll, T. (2022). Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients. PloS one, 17(7), e0271637.en_GB
dc.description.abstractObjective: Patients admitted to the Intensive Care Unit (ICU) oftentimes show immunological signs of immune suppression. Consequently, immune stimulatory agents have been proposed as an adjunctive therapy approach in the ICU. The objective of this study was to determine the relationship between the degree of immune suppression and systemic inflammation in patients shortly after admission to the ICU. Design: An observational study in two ICUs in the Netherlands. Methods: The capacity of blood leukocytes to produce cytokines upon stimulation with lipopolysaccharide (LPS) was measured in 77 patients on the first morning after ICU admission. Patients were divided in four groups based on quartiles of LPS stimulated tumor necrosis factor (TNF)-α release, reflecting increasing extents of immune suppression. 15 host response biomarkers indicative of aberrations in inflammatory pathways implicated in sepsis pathogenesis were measured in plasma. Results: A diminished capacity of blood leukocytes to produce TNF-α upon stimulation with LPS was accompanied by a correspondingly reduced ability to release of IL-1β and IL-6. Concurrently measured plasma concentrations of host response biomarkers demonstrated that the degree of reduction in TNF-α release by blood leukocytes was associated with increasing systemic inflammation, stronger endothelial cell activation, loss of endothelial barrier integrity and enhanced procoagulant responses. Conclusions: In patients admitted to the ICU the strongest immune suppression occurs in those who simultaneously display signs of stronger systemic inflammation. These findings may have relevance for the selection of patients eligible for administration of immune enhancing agents.en_GB
dc.publisherPublic Library of Scienceen_GB
dc.subjectCritically ill -- Careen_GB
dc.titleImmune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patientsen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.publication.titlePloS oneen_GB
Appears in Collections:Scholarly Works - FacHScABS

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.