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DC Field | Value | Language |
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dc.contributor.author | D’Adamo, Maria Cristina | - |
dc.contributor.author | Moro, Francesca | - |
dc.contributor.author | Imbrici, Paola | - |
dc.contributor.author | Martino, Dianda | - |
dc.contributor.author | Roscini, Mauro | - |
dc.contributor.author | Santorelli, Filippo Maria | - |
dc.contributor.author | Sicca, Federico | - |
dc.contributor.author | Pessia, Mauro | - |
dc.date.accessioned | 2015-01-30T10:59:29Z | - |
dc.date.available | 2015-01-30T10:59:29Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Malta Medical Journal. 2011, Vol.23(3), p. 10-14 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/1063 | - |
dc.description.abstract | Autism is a complex behavioral disorder that develops prior to age three years and is distinguished by high heritability. Many genes predisposing to autism spectrum disorders (ASDs) have been identified. These findings have demonstrated that ASDs are etiologically heterogeneous; although, the mutations underlying ASDs are identifiable only in a minority of patients. Indeed, the causes of ASDs are unknown in more than 70% of patients. Recently, we have described two unrelated families whose affected individuals display a characteristic triad of symptoms of autism; such as impairments in social interaction, impairments in communication, restricted interests and repetitive behavior. They also displayed other symptoms commonly observed in autistic individuals; such as gait imbalance, clumsiness, mental retardation and epilepsy. The genetic analysis of these families resulted in the identification of new heterozygous point mutations in the KCNJ10 gene that encodes the inwardly-rectifying K+ channel Kir4.1 expressed predominantly, but not exclusively, in astrocytes. Functionally, the mutated channels exhibited a phenotype consistent with gain-of-function defects. These new findings highlight the emerging role of inwardly-rectifying K+ channels and astrocyte dysfunction in autism spectrum disorders associated with epilepsy. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Malta Medical Journal | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Autism -- Diagnosis | en_GB |
dc.subject | Child development disorders, Pervasive | en_GB |
dc.subject | Epilepsy -- Etiology | en_GB |
dc.subject | Potassium channels | en_GB |
dc.title | The emerging role of the inwardly rectifying K+ channels in autism spectrum disorders and epilepsy | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | - |
Appears in Collections: | MMJ, Volume 23, Issue 3 MMJ, Volume 23, Issue 3 |
Files in This Item:
File | Description | Size | Format | |
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2011.Vol23.Issue3.A2.pdf | The emerging role of the inwardly rectifying K+ channels in autism spectrum disorders and epilepsy | 64.06 kB | Adobe PDF | View/Open |
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