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https://www.um.edu.mt/library/oar/handle/123456789/108995| Title: | NOD2/CARD15 mutations and phenotypic expression of Crohn’s disease in Malta |
| Authors: | Ellul, Pierre Azzopardi, Neville Saliba, Christian Grech Marguerat, Deborah LaFerla, Godfrey Grech, Godfrey |
| Keywords: | Crohn's disease -- Malta -- Case studies Inflammatory bowel diseases -- Malta -- Case studies Inflammatory bowel diseases -- Genetic aspects Nod2 signaling adaptor protein Toll-like receptor 4 |
| Issue Date: | 2012 |
| Publisher: | University of Malta. Medical School |
| Citation: | Ellul, P., Azzopardi, N., Saliba, C., Grech Marguerat, D., LaFerla, G., & Grech, G. (2012). NOD2/CARD15 mutations and phenotypic expression of Crohn’s disease in Malta. VIII Malta Medical School Conference abstract book, P4.13. |
| Abstract: | Background: Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with variations in localization and behaviour. Mutations in the NOD2/CARD15 gene on chromosome 16q have been implicated in the pathogenesis of the disease and three main sequence variants, all single nucleotide polymorphisms (SNPs), have been identified in North American and European populations. Data from mainland Europe has demonstrated a prevalence of 25-50% within CD patients. The genetic structure of the Maltese population includes Near Eastern Arab, Mediterranean and North African genetic components. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/108995 |
| ISSN: | 18133339 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| NOD2 CARD15 mutations and phenotypic expression of Crohn s disease in Malta 2012.pdf | 118.66 kB | Adobe PDF | View/Open |
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