1. OAR@UM
  2. Faculty of Medicine and Surgery
  3. Malta Medical Journal
  4. Malta Medical Journal, 2002-
  5. 2011
  6. MMJ, Volume 23, Issue 3
Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/1097
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dc.contributor.authorScerri, Charles-
dc.date.accessioned2015-02-02T15:51:12Z-
dc.date.available2015-02-02T15:51:12Z-
dc.date.issued2011-
dc.identifier.citationScerri, C. (2011). Effects of nicotine administration on amyloid precursor protein metabolism, neural cell genesis and acquisition of spatial memory. Malta Medical Journal, 23(1), 66-74.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/1097-
dc.description.abstractNicotine is reported to improve learning and memory in experimental animals. Improved learning and memory has also been related to increased neural cell genesis in the dentate gyrus of the brain hippocampal formation. Stimulation of acetylcholine receptors has also been found to enhance the expression and secretion of amyloid precursor protein (APP) in various cell lines. Aberrent metabolism of APP generates amyloid-beta (Abeta) peptide which is the major pathological lesion found in the brains of Alzheimer’s disease (AD) patients. This paper will focus on the the results obtained in our laboratory on the effects of acute and chronic nicotine administration on the metabolism of APP, its role in spatial learning and neural cell genesis in the rat brain.en_GB
dc.language.isoenen_GB
dc.publisherMalta Medical Journalen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectAmyloid beta-protein precursor -- Metabolismen_GB
dc.subjectNicotine -- Physiological effecten_GB
dc.subjectSpatial learningen_GB
dc.subjectReceptors, Cholinergic -- Stimulationen_GB
dc.titleEffects of nicotine administration on amyloid precursor protein metabolism, neural cell genesis and acquisition of spatial memoryen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-reviewed-
Appears in Collections:MMJ, Volume 23, Issue 3
MMJ, Volume 23, Issue 3
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