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dc.contributor.authorGrech, Alfred
dc.contributor.authorBaldacchino, Sandra
dc.identifier.citationGrech, A. & Baldacchino, S. (2012). HERVs, transposons and human diseases : part I. The Synapse, (6), 9-10en_GB
dc.descriptionPart 2 and part 3 of the article can be found through this link:
dc.description.abstractIt has been found that the human genome is full of relic retroviral DNA sequences called HERVs (Human Endogenous RetroViruses). A HERV is a type of a transposon, the latter being a piece of DNA sequence that can move from one position to another position in the genome, hence its other name of ‘jumping gene’. HERVs and other transposons are held in check from doing havoc in the genome by several mechanisms, one of which is epigenetic in nature (namely DNA methylation and histone modifications). HERVs and other transposons are being implicated to have physiological and pathological functions in the genomes of the cells that host them. Accumulating evidence is showing that they may be associated with certain human diseases, specifically in some autoimmune diseases (e.g. rheumatoid arthritis, psoriasis, systemic lupus erythematosus, insulin-dependent diabetes mellitus), neurological diseases (e.g. schizophrenia, multiple sclerosis, motor neuron disease) and cancer. Understanding how these relic viruses and other jumping genes bring about these human diseases could help in their prevention and treatment.en_GB
dc.publisherMedical Portals Ltd.en_GB
dc.subjectGenetic disordersen_GB
dc.titleHERVs, transposons and human diseases : part Ien_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
Appears in Collections:The Synapse, Issue 6
The Synapse, Issue 6

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