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dc.contributor.authorGrech, Alfred-
dc.contributor.authorBaldacchino, Alexandra-
dc.identifier.citationGrech, A. & Baldacchino, A. (2013). Epigenetic-based treatment as a potential strategy to treat Friedreich’s ataxia. The Synapse, (5), 10-12en_GB
dc.description.abstractFriedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder. It is the most common inherited ataxia in Europe. The neurodegeneration is progressive and normally, within 15-20 years, the patient becomes wheel-chair bound, and ultimately, is totally incapacitated. Affected individuals normally succumb from heart complications. Frataxin (FXN) is a mitochondrial protein that is deficient in FRDA. The deficiency is caused by a mutation within the first intron of the FXN gene which codes for frataxin. Epigenetic mechanisms are responsible in FRDA and epigenetic-based treatment is a potential new strategy to treat FRDA.en_GB
dc.publisherMedical Portals Ltd.en_GB
dc.subjectFriedreich's ataxiaen_GB
dc.subjectNervous system -- Diseases -- Treatmenten_GB
dc.subjectNervous system -- Degenerationen_GB
dc.titleEpigenetic-based treatment as a potential strategy to treat Friedreich’s ataxiaen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
Appears in Collections:The Synapse, Issue 5
The Synapse, Issue 5

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