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dc.contributor.authorGrech, Alfred-
dc.contributor.authorBaldacchino, Alexandra-
dc.identifier.citationGrech, A. & Baldacchino, A. (2014). Oncogene addiction might be the achilles heel in cancer : part I. The Synapse, 13(3), 20-21.en_GB
dc.descriptionPart 2 of the article can be found through this link:
dc.description.abstractMultiple and complex genetic and epigenetic abnormalities underlie the multistage transformation of normal cells into cancerous ones. Among these abnormalities are the activation of oncogenes and loss of function of tumour suppressor genes. Besides these abnormalities, it is becoming evident that specific cancers are dependent on one or a few genes for their malignant phenotype, and this could be their ‘Achilles heel’. This survival dependency of cancer cells on an activated oncogene or inactivation of tumour suppressor gene is called ‘oncogene addiction’ and may well be a potential way to provide more rational molecular targeted therapy. This strategy needs to integrate new approaches into the clinical setting in order to characterise the state of oncogene addiction and accordingly, apply more effective and selective anti-cancer therapies.en_GB
dc.publisherMedical Portals Ltd.en_GB
dc.subjectTumors -- Growthen_GB
dc.titleOncogene addiction might be the Achilles heel in cancer : part 1en_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
Appears in Collections:The Synapse, Volume 13, Issue 3
The Synapse, Volume 13, Issue 3

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