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dc.contributor.authorFenech, Anthony G.-
dc.contributor.authorGrech, Godfrey-
dc.identifier.citationFenech, A. G., & Grech, G. (2014). Pharmacogenetics and personalized medicine : does gender have a role? Journal of the Malta College of Pharmacy Practice, 20, 7-10.en_GB
dc.description.abstractThe study of the role of genetic polymorphisms in drug responses, is now a firmly established field of pharmacology research. It has robust applications in predicting drug effect, and therefore contributes to the process of optimum selection of drug and dose for specific patients. Since the last 10 years, the FDA as well as the EMA have set up their own pharmacogenomics advisory groups, and have flagged an increasing number of medicinal products with specific genotyping recommendations in order to reap their greatest benefit. The contribution of gender to therapeutic outcomes has long been recognised, but recent research suggests that gender influence may not only occur via well recognised hormonal pathways, but also via direct non-hormone-mediated mechanisms. This influence may confound pharmacogenetic predictors, and gender stratification may therefore be an important consideration in pharmacogenetic-based drug trials.en_GB
dc.publisherMalta College of Pharmacy Practiceen_GB
dc.subjectSex differencesen_GB
dc.subjectGenetic polymorphismsen_GB
dc.subjectDrug interactionsen_GB
dc.titlePharmacogenetics and personalized medicine : does gender have a role?en_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
Appears in Collections:JMCPP, Issue 20
JMCPP, Issue 20

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