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|Title:||Changes in bone collagen markers and in bone density in hormone treated and untreated postmenopausal women|
|Authors:||Galea, Raymond P.|
Muscat Baron, Yves
Brincat, Max P.
Menopause -- Hormone therapy
|Publisher:||Elsevier Science Ireland Ltd.|
|Citation:||Brincat, M., Galea, R., Muscat Baron, Y., & Xuereb, A. (1997). Changes in bone collagen markers and in bone density in hormone treated and untreated postmenopausal women. Maturitas, 27 (2), 171-177.|
|Abstract:||This study aims to compare bone mineral density measurements (BMD), pyridinium crosslink levels and pyridinium crosslink levels in untreated and hormone treated postmenopausal women. Methods: A cross-sectional study comparing biophysical (BMD) and biochemical (pyridinium crosslink and PCICP) parameters in a group of untreated postmenopausal women (n=145) to a group of postmenopausal women on hormone replacement therapy (HRT) (n=92). Results: Untreated postmenopausal women compared to postmenopausal women on HRT had higher Osteoblastic and Osteoclastic activity. Procollagen I C-end terminal peptide (PCICP) was 11.3% lower in the women on HRT compared to controls whilst crosslinks were 27.2% lower than in controls. This seems to indicate that women on HRT had a bone balance that was higher compared to the control group (15.9%). The difference in bone density of L2–L4 between the two groups was (16.1%). Conclusions: This study seems to indicate that postmenopausal women receiving HRT readjust their bone remodelling so that although osteoblastic function is reduced, there is a much greater deduction in osteoclastic function and this results in an overall higher bone mass observed in the BMD of women on HRT.|
|Appears in Collections:||Scholarly Works - FacHScABS|
Scholarly Works - FacM&SOG
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