Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/19209
Title: Gram negative wound infection in hospitalised adult burn patients--systematic review and metanalysis-
Authors: Azzopardi, Ernest A.
Azzopardi, Elayne
Camilleri, Liberato
Villapalos, Jorge
Boyce, Dean E.
Dziewulski, Peter
Dickson, William A.
Whitaker, Iain S.
Keywords: Gram-negative bacterial infections
Burns and scalds -- Complications
Hospital patients
Issue Date: 2014-04
Publisher: Public Library of Science
Citation: Azzopardi, E. A., Azzopardi, E., Camilleri, L., Villapalos, J., Boyce, D. E., Dziewulski, P., ... Whitaker, I. S. (2014). Gram negative wound infection in hospitalised adult burn patients--systematic review and metanalysis-. PLoS ONE, 9(4), 1-7.
Abstract: BACKGROUND: Gram negative infection is a major determinant of morbidity and survival. Traditional teaching suggests that burn wound infections in different centres are caused by differing sets of causative organisms. This study established whether Gram-negative burn wound isolates associated to clinical wound infection differ between burn centres. METHODS: Studies investigating adult hospitalised patients (2000-2010) were critically appraised and qualified to a levels of evidence hierarchy. The contribution of bacterial pathogen type, and burn centre to the variance in standardised incidence of Gram-negative burn wound infection was analysed using two-way analysis of variance. PRIMARY FINDINGS: Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumanni, Enterobacter spp., Proteus spp. and Escherichia coli emerged as the commonest Gram-negative burn wound pathogens. Individual pathogens' incidence did not differ significantly between burn centres (F (4, 20) = 1.1, p = 0.3797; r2 = 9.84). INTERPRETATION: Gram-negative infections predominate in burn surgery. This study is the first to establish that burn wound infections do not differ significantly between burn centres. It is the first study to report the pathogens responsible for the majority of Gram-negative infections in these patients. Whilst burn wound infection is not exclusive to these bacteria, it is hoped that reporting the presence of this group of common Gram-negative "target organisms" facilitate clinical practice and target research towards a defined clinical demand.
URI: https://www.um.edu.mt/library/oar//handle/123456789/19209
Appears in Collections:Scholarly Works - FacSciSOR

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