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dc.contributor.authorFenech, Anthony G.
dc.contributor.authorGrech, Godfrey
dc.identifier.citationXjenza. 2014, Vol.2(1), p. 14-31en_GB
dc.description.abstractThe study of pharmacogenetics has expanded from what were initially casual family-based clinical drug response observations, to a fully-fledged science with direct therapeutic applications, all within a time-span of less than 60 years. A wide spectrum of polymorphisms, located within several genes, are now recognised to influence the pharmacokinetics and pharmacodynamics of the majority of drugs within our therapeutic armamentarium. This information forms the basis for the new development of pharmacogenetic genotyping tests, which can be used to predict the therapeutic and/or adverse effects of a specific drug in a particular patient. Pharmacogenetic-guided, patient targeted therapy has now become the developing fulcrum of personalized medicine, as it provides the best means to optimize benefit/risk ratio in pharmacological management.en_GB
dc.publisherMalta Chamber of Scientistsen_GB
dc.subjectDrugs -- Testingen_GB
dc.subjectClinical pharmacologyen_GB
dc.titlePharmacogenetics : the science of predictive clinical pharmacologyen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
Appears in Collections:Xjenza, 2014, Volume 2, Issue 1
Xjenza, 2014, Volume 2, Issue 1

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