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dc.contributor.authorBlundell, Renald-
dc.contributor.authorHarrison, David J.-
dc.identifier.citationBlundell, R., & Harrison, D.J. (2007). Effect of changes in the extracellular matrix (ECM) composition on Clara cell proliferation and death through p21 regulation. Research Journal of Medical Sciences, 1(2), 62-69.en_GB
dc.description.abstractExtra Cellular Matrix (ECM) contains signals that control cell progression, division and death. Cell-matrix interactions or disruption affects the cell cycle regulation in various ways. In this study, Clara cells obtained form both wild type (wt) and p21 knockout (p21 ko) mice were isolated and cultured on different ECM combinations. Different ECM compositions did not influence Clara cells proliferation both the in presence or absence of p21. On the other hand, p21 was found to induce both apoptosis and necrosis in primary Clara cells cultures. The cell-matrix disruption rather than ECM composition seems to have a greater influence on the cell cycle regulation and progression.en_GB
dc.subjectExtracellular matrixen_GB
dc.subjectCell proliferationen_GB
dc.subjectCell deathen_GB
dc.titleEffect of changes in the extracellular matrix (ECM) composition on Clara cell proliferation and death through p21 regulationen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleResearch Journal of Medical Sciencesen_GB
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