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dc.contributor.authorPierucci, Massimo-
dc.contributor.authorChambers, Stephanie-
dc.contributor.authorPartridge, Lucy-
dc.contributor.authorDe Deurwaerdere, Philippe-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.identifier.citationPierucci, M., Chambers, S., Partridge, L., De Deurwaerdère, P., & Di Giovanni, G. (2014). Role of central serotonin receptors in nicotine addiction. In R. Lester (Ed.), Nicotinic receptors (pp. 279-305). New York: Humana Press.en_GB
dc.description.abstractRegulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including depression, anxiety, schizophrenia and Parkinson’s disorders. There is also a great amount of evidence indicating that 5-HT signalling may affect the reinforcing properties of drugs of abuse by the interaction and modulation of dopamine (DA) function. This chapter is focused on one of the more addictive drugs, nicotine. It is widely recognised that the effects of nicotine are strongly associated with the stimulatory action it exhibits on mesolimbic DAergic function. We outline the role of 5-HT and its plethora of receptors, focusing on 5-HT2 subtypes with relation to their involvement in the neurobiology of nicotine addiction. We also explore the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT2C receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required.en_GB
dc.publisherHumana Pressen_GB
dc.subjectReceptor, Serotonin, 5-HT2Cen_GB
dc.subjectNicotine addiction -- Treatmenten_GB
dc.subjectSmoking cessationen_GB
dc.subjectParkinson's diseaseen_GB
dc.titleRole of central serotonin receptors in nicotine addictionen_GB
dc.title.alternativeNicotinic receptorsen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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