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Title: Role of central serotonin receptors in nicotine addiction
Other Titles: Nicotinic receptors
Authors: Pierucci, Massimo
Chambers, Stephanie
Partridge, Lucy
De Deurwaerdere, Philippe
Di Giovanni, Giuseppe
Keywords: Nicotine
Receptor, Serotonin, 5-HT2C
Nicotine addiction -- Treatment
Smoking cessation
Parkinson's disease
Issue Date: 2014
Publisher: Humana Press
Citation: Pierucci, M., Chambers, S., Partridge, L., De Deurwaerdère, P., & Di Giovanni, G. (2014). Role of central serotonin receptors in nicotine addiction. In R. Lester (Ed.), Nicotinic receptors (pp. 279-305). New York: Humana Press.
Abstract: Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including depression, anxiety, schizophrenia and Parkinson’s disorders. There is also a great amount of evidence indicating that 5-HT signalling may affect the reinforcing properties of drugs of abuse by the interaction and modulation of dopamine (DA) function. This chapter is focused on one of the more addictive drugs, nicotine. It is widely recognised that the effects of nicotine are strongly associated with the stimulatory action it exhibits on mesolimbic DAergic function. We outline the role of 5-HT and its plethora of receptors, focusing on 5-HT2 subtypes with relation to their involvement in the neurobiology of nicotine addiction. We also explore the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT2C receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required.
ISBN: 9781493911660
Appears in Collections:Scholarly Works - FacM&SPB

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