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Title: Predicting dopaminergic effects of L-DOPA in the treatment for Parkinson's disease
Authors: Navailles, Sylvia
Di Giovanni, Giuseppe
De Deurwaerdere, Philippe
Keywords: Parkinson's disease -- Treatment
Issue Date: 2014
Publisher: Wiley-Blackwell Publishing Ltd.
Citation: Navailles, S., Di Giovanni, G., & De Deurwaerdère, P. (2014). Predicting dopaminergic effects of L-DOPA in the treatment for Parkinson's disease. CNS Neuroscience & Therapeutics, 20(7), 699-701.
Abstract: Numerous advances have been made in the understanding of the mechanism of action of the antiparkinsonian medicine L-DOPA. This has allowed for the development of interesting predictive models regarding the positive and side effects of this medication. Recently, a mathematical model has been developed to investigate the impact of L-DOPA on dopamine (DA) release from serotonergic (5-HT) terminals in the striatum. The parameters used to elaborate this model were partially based on experimental data and may not be sufficient to illustrate the biochemical effects of L-DOPA inside 5-HT terminals.
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