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DC Field | Value | Language |
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dc.contributor.author | Simic, Goran | - |
dc.contributor.author | Babic Leko, Mirjana | - |
dc.contributor.author | Wray, Selina | - |
dc.contributor.author | Harrington, Charles R. | - |
dc.contributor.author | Delalle, Ivana | - |
dc.contributor.author | Jovanov-Milosevic, Natasa | - |
dc.contributor.author | Bazadona, Danira | - |
dc.contributor.author | Buee, Luc | - |
dc.contributor.author | De Silva, Rohan | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Wischik, Claude M. | - |
dc.contributor.author | Hof, Patrick R. | - |
dc.date.accessioned | 2017-10-13T16:51:15Z | - |
dc.date.available | 2017-10-13T16:51:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov-Milošević, N...,Hof, P. R. (2016). Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules, 6, 1. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22587 | - |
dc.description.abstract | Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases, including Alzheimer’s disease (AD). AD is characterized by the extraneuronal deposition of the amyloid β (Aβ) protein in the form of plaques and the intraneuronal aggregation of the microtubule-associated protein tau in the form of filaments. Based on the biochemically diverse range of pathological tau proteins, a number of approaches have been proposed to develop new potential therapeutics. Here we discuss some of the most promising ones: inhibition of tau phosphorylation, proteolysis and aggregation, promotion of intra- and extracellular tau clearance, and stabilization of microtubules. We also emphasize the need to achieve a full understanding of the biological roles and post-translational modifications of normal tau, as well as the molecular events responsible for selective neuronal vulnerability to tau pathology and its propagation. It is concluded that answering key questions on the relationship between Aβ and tau pathology should lead to a better understanding of the nature of secondary tauopathies, especially AD, and open new therapeutic targets and strategies. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | MDPIAG | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Alzheimer's disease | en_GB |
dc.subject | Amyloid beta-protein | en_GB |
dc.subject | Nervous system -- Diseases | en_GB |
dc.subject | Nervous system -- Degeneration | en_GB |
dc.subject | Tau proteins | en_GB |
dc.title | Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3390/biom6010006 | - |
dc.publication.title | Biomolecules | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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biomolecules-06-00006-v2.pdf | 3.84 MB | Adobe PDF | View/Open |
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