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dc.contributor.authorDi Giovanni, Giuseppe
dc.contributor.authorMatteo, Vincenzo di
dc.contributor.authorPierucci, Massimo
dc.contributor.authorBenigno, Arcangelo
dc.contributor.authorEsposito, Ennio
dc.identifier.citationDi Giovanni, G., Di Matteo, V., Pierucci, M., Benigno, A., & Esposito, E. (2006). Central serotonin2C receptor : from physiology to pathology. Current Topics in Medicinal Chemistry, 6(18), 1909-1925.en_GB
dc.description.abstractSince the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has explored the pathophysiological role of one of these receptors, the 5-HT2C receptor, that has been emerged as a prominent central serotonin receptor subtype. The physiology, pharmacology and anatomical distribution of the 5-HT2C receptors in the CNS will be firstly reviewed. Finally, their potential involvement in the pathophysiology of depression, schizophrenia, Parkinson's disease and drug abuse will be also discussed.en_GB
dc.publisherBentham Science Publishers Ltd.en_GB
dc.subjectReceptor, Serotonin, 5-HTen_GB
dc.subjectDepression, Mentalen_GB
dc.subjectReceptor, Serotonin, 5-HT2Cen_GB
dc.titleCentral serotonin2C receptor : from physiology to pathologyen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleCurrent Topics in Medicinal Chemistryen_GB
Appears in Collections:Scholarly Works - FacM&SPB

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