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Title: | Central serotonin2C receptor : from physiology to pathology |
Authors: | Di Giovanni, Giuseppe Di Matteo, Vincenzo Pierucci, Massimo Benigno, Arcangelo Esposito, Ennio |
Keywords: | Serotonin Receptor, Serotonin, 5-HT Depression, Mental Schizophrenia Receptor, Serotonin, 5-HT2C |
Issue Date: | 2006 |
Publisher: | Bentham Science Publishers Ltd. |
Citation: | Di Giovanni, G., Di Matteo, V., Pierucci, M., Benigno, A., & Esposito, E. (2006). Central serotonin2C receptor : from physiology to pathology. Current Topics in Medicinal Chemistry, 6(18), 1909-1925. |
Abstract: | Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has explored the pathophysiological role of one of these receptors, the 5-HT2C receptor, that has been emerged as a prominent central serotonin receptor subtype. The physiology, pharmacology and anatomical distribution of the 5-HT2C receptors in the CNS will be firstly reviewed. Finally, their potential involvement in the pathophysiology of depression, schizophrenia, Parkinson's disease and drug abuse will be also discussed. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/22595 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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CTMC reprint.pdf | 1.91 MB | Adobe PDF | View/Open |
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