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DC Field | Value | Language |
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dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Di Matteo, Vincenzo | - |
dc.contributor.author | La Grutta, Vittorio | - |
dc.contributor.author | Esposito, Ennio | - |
dc.date.accessioned | 2017-10-13T17:33:42Z | - |
dc.date.available | 2017-10-13T17:33:42Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Di Giovanni, G., Di Matteo, V., La Grutta, V., & Esposito, E. (2001). m-Chlorophenylpiperazine, excites non-dopaminergic neurons in the rat Substantia Nigra and Ventral Tegmental Area by activating serotonin-2c receptors. Neuroscience, 103(1), 111-116. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22597 | - |
dc.description.abstract | In vivo electrophysiological techniques were used to study the effect of m-chlorophenylpiperazine, a non-selective serotonin-2C receptor agonist, on the activity of non-dopaminergic neurons in the substantia nigra pars reticulata and the ventral tegmental area of anesthetized rats. Intravenous administration of m-chlorophenylpiperazine (5–320 μg/kg) caused a dose-dependent increase in the basal firing rate of a subpopulation of nigral neurons which do not respond to a footpinch stimulus [P(0) neurons], whereas it did not affect the activity of neurons which are responsive to the footpinch [P(+) neurons]. However, m-chlorophenylpiperazine (5–320 μg/kg) excited all non-dopaminergic neurons sampled in the ventral tegmental area. Moreover, microiontophoretic application of m-chlorophenylpiperazine (10–40 nA) caused an excitation of P(0) nigral and ventral tegmental area neurons. Pretreatment with the selective serotonin-2C receptor antagonist SB 242084 (200 μg/kg, i.v.) completely blocked the excitatory effect of i.v. m-chlorophenylpiperazine (5–320 μg/kg), both in the substantia nigra pars reticulata and in the ventral tegmental area. It is concluded that stimulation of serotonin-2C receptors by m-chlorophenylpiperazine activates non-dopaminergic (presumably GABA-containing) neurons in the substantia nigra pars reticulata and ventral tegmental area. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Pergamon Press | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Receptor, Serotonin, 5-HT2C | en_GB |
dc.subject | Electrophysiology | en_GB |
dc.subject | Ventral tegmental area | en_GB |
dc.subject | Zona reticularis | en_GB |
dc.subject | GABAergic neurons | en_GB |
dc.title | m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat Substantia Nigra and Ventral Tegmental Area by activating serotonin-2c receptors | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/S0306-4522(00)00561-3 | - |
dc.publication.title | Neuroscience | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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