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DC Field | Value | Language |
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dc.contributor.author | D'Adamo, Maria Cristina | - |
dc.contributor.author | Servettini, Ilenio | - |
dc.contributor.author | Guglielmi, Luca | - |
dc.contributor.author | Di Matteo, Vincenzo | - |
dc.contributor.author | Di Maio, Roberto | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Pessia, Mauro | - |
dc.date.accessioned | 2017-10-14T08:48:42Z | - |
dc.date.available | 2017-10-14T08:48:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | D'Adamo, M. C., Servettini, I., Guglielmi, L., Di Matteo, V., Di Maio, R., Di Giovanni, G., & Pessia, M. (2013). 5-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates. Experimental Brain Research, 230(4), 453-462. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22606 | - |
dc.description.abstract | The activity of voltage-gated K(+) channels (Kv) can be dynamically modulated by several events, including neurotransmitter stimulated biochemical cascades mediated by G protein-coupled receptors such as 5-HT2 receptors (5-HT2Rs). Activation of 5-HT2A/CR inhibits the Shaker-like K(+) channels Kv1.1 and Kv1.2, and this modulation involves the dual coordination of both RPTPĪ± and distinct tyrosine kinases coupled to this receptor; 5-HT2Rs-mediated modulation of Kv channels controls glutamate release onto prefrontal cortex neurons that might play critical roles in neurophysiological, neurological, and psychiatric conditions. Noticeably, hallucinogens modulate Kv channel activity, acting at 5-HT2R. Hence, comprehensive knowledge of 5-HT2R signaling through modulation of distinct K(+) channels is a pivotal step in the direction that will enable scientists to discover novel 5-HT functions and dysfunctions in the brain and to identify original therapeutic targets. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Receptor, Serotonin, 5-HT2C | en_GB |
dc.subject | Receptor, Serotonin, 5-HT2A | en_GB |
dc.subject | Kv1.1 potassium channel | en_GB |
dc.subject | Kv1.2 potassium channel | en_GB |
dc.title | 5-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/s00221-013-3555-8 | - |
dc.publication.title | Experimental Brain Research | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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File | Description | Size | Format | |
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DAdamo et al EBR 2013.pdf | 548.72 kB | Adobe PDF | View/Open |
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