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DC Field | Value | Language |
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dc.contributor.author | Connelly, William M. | - |
dc.contributor.author | Fyson, Sarah J. | - |
dc.contributor.author | Errington, Adam C. | - |
dc.contributor.author | McCafferty, Cian P. | - |
dc.contributor.author | Cope, David W. | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Crunelli, Vincenzo | - |
dc.date.accessioned | 2017-10-16T08:39:43Z | - |
dc.date.available | 2017-10-16T08:39:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Connelly, B., Fyson, S. J., Errington, A. C., Mccafferty, C., Cope, D. W., Di Giovanni, G., & Crunelli, V. (2013). GABAB receptors regulate extrasynaptic GABAA receptors. Journal of Neuroscience, 33(9), 3780-3785. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22611 | - |
dc.description.abstract | Tonic inhibitory GABAA receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABAB receptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G proteins, adenylate cyclase, and cAMP-dependent protein kinase. Using a combination of pharmacology and knockout mice, we show that this pathway is independent of potassium channels or GABA transporters. Furthermore, the enhancement in tonic current is sufficient to significantly alter the excitability of thalamocortical neurons. These results demonstrate for the first time a postsynaptic crosstalk between GABAB and GABAA receptors. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Society for Neuroscience | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Receptors, GABA-A | en_GB |
dc.subject | Receptors, GABA-B | en_GB |
dc.title | GABAB receptors regulate extrasynaptic GABAA receptors | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1523/JNEUROSCI.4989-12.2013 | - |
dc.publication.title | Journal of Neuroscience | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Connelly et al 2013.pdf | 1.09 MB | Adobe PDF | View/Open |
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