Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/22618
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Svob Strac, Dubravka | - |
dc.contributor.author | Pivac, Nela | - |
dc.contributor.author | Smolders, Ilse J. | - |
dc.contributor.author | Fogel, Wieslawa A. | - |
dc.contributor.author | De Deurwaerdère, Philippe | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.date.accessioned | 2017-10-16T09:29:21Z | - |
dc.date.available | 2017-10-16T09:29:21Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Svob Strac, D., Nela, P., Smolders, I. J., Fogel, W. A., De Deurwaerdere, P., & Di Giovanni, G. (2016). Monoaminergic mechanisms in epilepsy may offer innovative therapeutic opportunity for monoaminergic multi-target drugs. Frontiers in Neuroscience, 10, 492. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22618 | - |
dc.description.abstract | A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another. In this review, we will focus on the role of serotonin, dopamine, noradrenaline, histamine, and melatonin in epilepsy. Recent experimental, clinical, and genetic evidence will be reviewed in consideration of the mutual relationship of monoamines with the other putative neurotransmitters. The complexity of epileptic pathogenesis may explain why the currently available drugs, developed according to the classic drug discovery paradigm of “one-molecule-one-target,” have turned out to be effective only in a percentage of PWE. Although, no antiepileptic drugs currently target specifically monoaminergic systems, multi-target directed ligands acting on different monoaminergic proteins, present on both neurons and glia cells, may represent a new approach in the management of seizures, and their generation as well as comorbid neuropsychiatric disorders. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Research Foundation | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Epilepsy | en_GB |
dc.subject | Anticonvulsants | en_GB |
dc.subject | Astrocytes | en_GB |
dc.subject | Microglia | en_GB |
dc.title | Monoaminergic mechanisms in epilepsy may offer innovative therapeutic opportunity for monoaminergic multi-target drugs | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3389/fnins.2016.00492 | - |
dc.publication.title | Frontiers in Neuroscience | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Monoaminergic_Mechanisms_in_Epilepsy_May_Offer_Inn.pdf | 926.37 kB | Adobe PDF | View/Open |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.