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dc.contributor.authorDe Deurwaerdere, Philippe
dc.contributor.authorDi Giovanni, Giuseppe
dc.date.accessioned2017-10-17T10:27:27Z
dc.date.available2017-10-17T10:27:27Z
dc.date.issued2015
dc.identifier.citationDe Deurwaerdère, P., & Di Giovanni, G. (2016). Serotonergic modulation of the activity of mesencephalic dopaminergic systems : therapeutic implications. Progress in Neurobiology, 151, 175-236.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/22752
dc.description.abstractSince their discovery in the mammalian brain, it has been apparent that serotonin (5-HT) and dopamine (DA) interactions play a key role in normal and abnormal behavior. Therefore, disclosure of this interaction could reveal important insights into the pathogenesis of various neuropsychiatric diseases including schizophrenia, depression and drug addiction or neurological conditions such as Parkinson’s disease and Tourette’s syndrome. Unfortunately, this interaction remains difficult to study for many reasons, including the rich and widespread innervations of 5-HT and DA in the brain, the plethora of 5-HT receptors and the release of co-transmitters by 5-HT and DA neurons. The purpose of this review is to present electrophysiological and biochemical data showing that endogenous 5-HT and pharmacological 5-HT ligands modify the mesencephalic DA systems’ activity. 5-HT receptors may control DA neuron activity in a state-dependent and region-dependent manner. 5-HT controls the activity of DA neurons in a phasic and excitatory manner, except for the control exerted by 5-HT2C receptors which appears to also be tonically and/or constitutively inhibitory. The functional interaction between the two monoamines will also be discussed in view of the mechanism of action of antidepressants, antipsychotics, anti-Parkinsonians and drugs of abuse.en_GB
dc.language.isoenen_GB
dc.publisherPergamon Pressen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectReceptors, Serotoninen_GB
dc.subjectAntidepressantsen_GB
dc.subjectAntipsychotic drugsen_GB
dc.subjectElectrophysiologyen_GB
dc.titleSerotonergic modulation of the activity of mesencephalic dopaminergic systems : therapeutic implicationsen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/j.pneurobio.2016.03.004
dc.publication.titleProgress in Neurobiologyen_GB
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