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dc.contributor.authorMatteo, Vincenzo di
dc.contributor.authorPierucci, Massimo
dc.contributor.authorBenigno, Arcangelo
dc.contributor.authorCrescimanno, Giuseppe
dc.contributor.authorEsposito, Ennio
dc.contributor.authorDi Giovanni, Giuseppe
dc.identifier.citationDi Matteo, V., Pierucci, M., Benigno, A., Crescimanno, G., Esposito, E., & Di Giovanni, G. (2009). Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration : a neurochemical study. Annals of the New York Academy of Sciences, 1155, 309-315.en_GB
dc.description.abstractThe present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD.en_GB
dc.publisherWiley-Blackwell Publishing, Inc.en_GB
dc.subjectParkinson's diseaseen_GB
dc.subjectNitric oxideen_GB
dc.subjectCorpus striatumen_GB
dc.subjectSubstantia nigraen_GB
dc.titleInvolvement of nitric oxide in nigrostriatal dopaminergic system degeneration : a neurochemical studyen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleAnnals of the New York Academy of Sciencesen_GB
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