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DC Field | Value | Language |
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dc.contributor.author | Venzi, Marcello | |
dc.contributor.author | David, Francois | |
dc.contributor.author | Bellet, Joachim | |
dc.contributor.author | Cavaccini, Anna | |
dc.contributor.author | Bombardi, Cristiano | |
dc.contributor.author | Crunelli, Vincenzo | |
dc.contributor.author | Di Giovanni, Giuseppe | |
dc.date.accessioned | 2017-10-17T14:17:36Z | |
dc.date.available | 2017-10-17T14:17:36Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V., & Di Giovanni, G. (2016). Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology, 108, 292-304. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22786 | |
dc.description.abstract | Absence seizures (ASs) are the hallmark of childhood/juvenile absence epilepsy. Monotherapy with first-line anti-absence drugs only controls ASs in 50% of patients, indicating the need for novel therapeutic targets. Since serotonin family-2 receptors (5-HT2Rs) are known to modulate neuronal activity in the cortico-thalamo-cortical loop, the main network involved in AS generation, we investigated the effect of selective 5-HT2AR and 5-HT2CR ligands on ASs in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a well established polygenic rat model of these non-convulsive seizures. GAERS rats were implanted with fronto-parietal EEG electrodes under general anesthesia, and their ASs were later recorded under freely moving conditions before and after intraperitoneal administration of various 5-HT2AR and 5-HT2CR ligands. The 5-HT2A agonist TCB-2 dose-dependently decreased the total time spent in ASs, an effect that was blocked by the selective 5-HT2A antagonist MDL11,939. Both MDL11,939 and another selective 5-HT2A antagonist (M100,907) increased the length of individual seizures when injected alone. The 5-HT2C agonists lorcaserin and CP-809,101 dose-dependently suppressed ASs, an effect blocked by the selective 5-HT2C antagonist SB 242984. In summary, 5-HT2ARs and 5-HT2CRs negatively control the expression of experimental ASs, indicating that selective agonists at these 5-HT2R subtypes might be potential novel anti-absence drugs. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Pergamon Press | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | Receptor, Serotonin, 5-HT | en_GB |
dc.subject | Epilepsy, Absence | en_GB |
dc.title | Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.neuropharm.2016.04.016 | |
dc.publication.title | Neuropharmacology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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venzi et al 2016, Final.pdf | 2.51 MB | Adobe PDF | View/Open |
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