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DC Field | Value | Language |
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dc.contributor.author | Salvadè, Agnese | - |
dc.contributor.author | D'Angelo, Vincenza | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Tinkhauser, Gerd | - |
dc.contributor.author | Sancesario, Giuseppe | - |
dc.contributor.author | Stadler, Claudio | - |
dc.contributor.author | Moller, Jens C. | - |
dc.contributor.author | Stefani, Alessandro | - |
dc.contributor.author | Kaelin-Lang, Alain | - |
dc.contributor.author | Galati, Salvatore | - |
dc.date.accessioned | 2017-10-17T14:54:44Z | - |
dc.date.available | 2017-10-17T14:54:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Salvadè, A., D'angelo, V., Di Giovanni, G., Tinkhauser, G., Sancesario, G., Städler, C..., Galati, S. (2016). Distinct roles of cortical and pallidal β and γ frequencies in hemiparkinsonian and dyskinetic rats. Experimental Neurology, 275(1), 199-208. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22794 | - |
dc.description.abstract | Enhanced β band (βB) activity, which is suppressed by levodopa (LD) treatment, has been demonstrated within the basal ganglia (BG) of Parkinson's disease (PD) patients. However, some data suggest that Parkinsonian symptoms are not directly related to this brain frequency and therefore, its causative role remains questionable. A less explored phenomenon is the link between the γ band (γB) and PD phenomenology. Here, we monitored the development of the oscillatory activity during chronic LD depletion and LD treatment in Parkinsonian and levodopa-induced dyskinesia (LID) in rats. We found a significant and bilateral power increase in the high βB frequencies (20–30 Hz) within the first 10 days after 6-hydroxydopamine (6-OHDA) lesion, which was in accordance with a significant depletion of dopaminergic fibers in the striatum. We also observed a clear-cut γB increase during LD treatment. The development of LID was characterized by a slight increase in the cumulative power of βB accompanied by a large augmentation in the γB frequency (60–80 Hz). This latter effect reached a plateau in the frontal cortex bilaterally and the left globus pallidus after the second week of LD treatment. Our data suggest that the βB parallels the emergence of Parkinsonian signs and can be taken as a predictive sign of DA depletion, matching TH-staining reduction. On the other hand, the γB is strictly correlated to the development of LID. LD treatment had an opposite effect on βB and γB, respectively. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Academic Press | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Parkinson's disease | en_GB |
dc.subject | Rats as laboratory animals | en_GB |
dc.title | Distinct roles of cortical and pallidal beta and gamma frequencies in hemiparkinsonian and dyskinetic rats | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.expneurol.2015.11.005 | - |
dc.publication.title | Experimental Neurology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Salvade` 2015.pdf | 2.39 MB | Adobe PDF | View/Open |
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