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dc.contributor.authorOrban, Gergely-
dc.contributor.authorPierucci, Massimo-
dc.contributor.authorBenigno, Arcangelo-
dc.contributor.authorPessia, Mauro-
dc.contributor.authorGalati, Salvatore-
dc.contributor.authorValentino, Mario-
dc.contributor.authorMuscat, Richard-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.identifier.citationOrban, G., Pierucci, M., Benigno, A., Pessia, M., Galati, S., Valentino, M., Muscat, R., & Di Giovanni, G. (2013). High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo. Experimental Brain Research, 230(4), 441-451.en_GB
dc.description.abstractAlthough several studies have emphasized a crucial role for the serotonergic system in the control of hippocampal excitability, the role of serotonin (5-HT) and its receptors in normal and pathologic conditions, such as temporal lobe epilepsy (TLE), is still unclear. The present study was therefore designed firstly to investigate the acute effect of 8-OH-DPAT, a mixed 5-HT1A/7 receptor agonist, at a high dose (1 mg/kg, i.p.) known to have antiepileptic properties, in a model of acute partial epilepsy in rats. For this purpose, a maximal dentate activation (MDA) protocol was used to measure electrographic seizure onset and duration. In addition, the effect of 8-OH-DPAT on in vivo dentate gyrus cell reactivity and short- and long-term plasticity was studied. Rats injected with 8-OH-DPAT exhibited a significant reduction in MDA and epileptic discharges, a decrease in paired-pulse facilitation and an increase in long-term potentiation. This study suggests that 8-OH-DPAT or in general 5-HT1A/7 agonists might be useful for the treatment of TLE and also have some beneficial effects on the comorbid cognitive disorders seen in epileptic patients.en_GB
dc.subjectTemporal lobe epilepsyen_GB
dc.subjectDentate gyrusen_GB
dc.subjectReceptors, Serotoninen_GB
dc.subjectDepression, Mentalen_GB
dc.titleHigh dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivoen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleExperimental Brain Researchen_GB
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