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DC Field | Value | Language |
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dc.contributor.author | Ruggieri, Silvia | - |
dc.contributor.author | Drago, Gaspare | - |
dc.contributor.author | Longo, Valeria | - |
dc.contributor.author | Colombo, Paolo | - |
dc.contributor.author | Balzan, Martin | - |
dc.contributor.author | Bilocca, David | - |
dc.contributor.author | Zammit, Christopher | - |
dc.contributor.author | Montefort, Stephen | - |
dc.contributor.author | Scaccianoce, Gianluca | - |
dc.contributor.author | Cuttitta, Giuseppina | - |
dc.contributor.author | Viegi, Giovanni | - |
dc.contributor.author | Cibella, Fabio | - |
dc.date.accessioned | 2017-10-31T08:16:54Z | - |
dc.date.available | 2017-10-31T08:16:54Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Ruggieri, S., Drago, G., Longo, V., Colombo, P., Balzan, M., Bilocca, D.,... The RESPIRA Project Group. (2017). Sensitization to dust mite defines different phenotypes of asthma: a multicenter study. Pediatric Allergy and Immunology, | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/23102 | - |
dc.description | The authors thank the study participants, their parents, their teachers, and the schools involved for their active participation in the study. This work was supported by the Operational Programme Italy-Malta 2007-2013, Project code A1.2.3-72. | en_GB |
dc.description.abstract | Background: Indoor allergens are risk factors for asthma: Thus, the characterization of indoor air quality is important for studying environment–health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. Methods: One hundred and thirty-two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires. Spirometry, exhaled nitric oxide (FeNO), skin prick tests, total, and specific serum IgE analyses were performed along with the evaluation of home dust samples for the content in Der p 1 allergen. Three clusters were created on the basis of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1-specific IgE level. Results: Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25%-75%), while its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE). Cluster 3 (Wh12m−/low IgE) showed the lowest FeNO values and pulmonary function similar to Cluster 2. Within Cluster 1, both Der p 1-specific IgE and FeNO were positively correlated with dust Der p 1. Conclusions: Similar asthma phenotypes may occur in children despite differences in their atopic state. In atopic children, sensitizing allergens in the indoor environment may increase airway inflammation worsening pulmonary function. Moreover, environmental exposures may contribute to the development of asthma-like symptoms also in the absence of atopic sensitization, thus contributing to asthma overdiagnosis. | en_GB |
dc.description.sponsorship | Operational Programme Italy-Malta 2007-2013, Grant/Award Number: A1.2.3-72 | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Allergens | en_GB |
dc.subject | Spirometry | en_GB |
dc.subject | Asthma -- Mediterranean Region | en_GB |
dc.title | Sensitization to dust mite defines different phenotypes of asthma : a multicenter study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.contributor.corpauthor | The RESPIRA Project Group | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1111/pai.12768 | - |
dc.publication.title | Pediatric Allergy and Immunology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
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Sensitization to dust mite defines different phenotypes of asthma_a multicenter study.pdf Restricted Access | 493.34 kB | Adobe PDF | View/Open Request a copy |
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