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dc.contributor.authorRuggieri, Silvia-
dc.contributor.authorDrago, Gaspare-
dc.contributor.authorLongo, Valeria-
dc.contributor.authorColombo, Paolo-
dc.contributor.authorBalzan, Martin-
dc.contributor.authorBilocca, David-
dc.contributor.authorZammit, Christopher-
dc.contributor.authorMontefort, Stephen-
dc.contributor.authorScaccianoce, Gianluca-
dc.contributor.authorCuttitta, Giuseppina-
dc.contributor.authorViegi, Giovanni-
dc.contributor.authorCibella, Fabio-
dc.identifier.citationRuggieri, S., Drago, G., Longo, V., Colombo, P., Balzan, M., Bilocca, D.,... The RESPIRA Project Group. (2017). Sensitization to dust mite defines different phenotypes of asthma: a multicenter study. Pediatric Allergy and Immunology,en_GB
dc.descriptionThe authors thank the study participants, their parents, their teachers, and the schools involved for their active participation in the study. This work was supported by the Operational Programme Italy-Malta 2007-2013, Project code A1.2.3-72.en_GB
dc.description.abstractBackground: Indoor allergens are risk factors for asthma: Thus, the characterization of indoor air quality is important for studying environment–health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. Methods: One hundred and thirty-two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires. Spirometry, exhaled nitric oxide (FeNO), skin prick tests, total, and specific serum IgE analyses were performed along with the evaluation of home dust samples for the content in Der p 1 allergen. Three clusters were created on the basis of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1-specific IgE level. Results: Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25%-75%), while its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE). Cluster 3 (Wh12m−/low IgE) showed the lowest FeNO values and pulmonary function similar to Cluster 2. Within Cluster 1, both Der p 1-specific IgE and FeNO were positively correlated with dust Der p 1. Conclusions: Similar asthma phenotypes may occur in children despite differences in their atopic state. In atopic children, sensitizing allergens in the indoor environment may increase airway inflammation worsening pulmonary function. Moreover, environmental exposures may contribute to the development of asthma-like symptoms also in the absence of atopic sensitization, thus contributing to asthma overdiagnosis.en_GB
dc.description.sponsorshipOperational Programme Italy-Malta 2007-2013, Grant/Award Number: A1.2.3-72en_GB
dc.subjectAsthma -- Mediterranean Regionen_GB
dc.titleSensitization to dust mite defines different phenotypes of asthma : a multicenter studyen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.contributor.corpauthorThe RESPIRA Project Groupen_GB
dc.publication.titlePediatric Allergy and Immunologyen_GB
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