Physicochemical properties of ciprofloxacin formulations

Abstract

Tablets are produced from formulations, which generally consist of an active ingredient and a number of excipients. The functions of excipients are various and include fillers, used to add adhesion between powder particles, glidants, used to lubricate the powder and aid flow by reducing interpaticulate friction and cohesion, and lubricants, used to aid the release of tablets from high speed tableting presses. The importance of achieving optimal flowability is that many stages of the manufacturing process are affected by this property, including the transfer of powder through large equipment, blending, compaction and fluidization. The objective of this study was to investigate the physicochemical properties of a number of ciprofloxacin hydrochloride formulations.