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dc.contributor.authorBeasley, Richard
dc.contributor.authorClayton, Tadd O.
dc.contributor.authorCrane, Julian
dc.contributor.authorLai, Christopher K. W.
dc.contributor.authorMontefort, Stephen
dc.contributor.authorVon Mutius, Erika
dc.contributor.authorStewart, Alistair W.
dc.identifier.citationBeasley, R., Clayton, T., Crane, J., Lai, C.K., Montefort, S., Von Mutius, E.,...ISAAC Phase III Study Group (2011). Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents : ISAAC Phase Three. American Journal of Respiratory and Critical Care Medicine, 183(2), 171-178.en_GB
dc.description.abstractRationale: There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma. Objectives: To investigate the risk of asthma and other allergic disorders associated with the current use of acetaminophen in 13- to 14-year-old children in different populations worldwide. Methods: As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three, 13- to 14-year-old children completed written and video questionnaires obtaining data on current symptoms of asthma, rhinoconjunctivitis, and eczema, and a written environmental questionnaire obtaining data on putative risk factors, including acetaminophen use in the past 12 months. Measurements and Main Results: The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression. A total of 322,959 adolescent children from 113 centers in 50 countries participated. In the multivariate analyses the recent use of acetaminophen was associated with an exposure-dependent increased risk of current asthma symptoms (OR, 1.43 [95% confidence interval, 1.33–1.53] and 2.51 [95% confidence interval, 2.33–2.70] for medium and high versus no use, respectively). Acetaminophen use was also associated with an exposure-dependent increased risk of current symptoms of rhinoconjunctivitis and eczema. Conclusions: Acetaminophen use may represent an important risk factor for the development and/or maintenance of asthma, rhinoconjunctivitis, and eczema in adolescent children.en_GB
dc.publisherAmerican Thoracic Societyen_GB
dc.subjectAsthma in childrenen_GB
dc.subjectEczema in childrenen_GB
dc.titleAcetaminophen use and risk of asthma, rhinoconjunctivitis and eczema in adolescents : ISAAC Phase Threeen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.contributor.corpauthorISAAC Phase Three Study Groupen_GB
dc.publication.titleAmerican Journal of Respiratory and Critical Care Medicineen_GB
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