Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/23180
Title: | Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects |
Authors: | Peroni, Diego Giampietro Djukanovic, Ratko Bradding, Peter B. Feather, Iain H. Montefort, Stephen Howarth, Peter Hugo Jones, David B. Holgate, Stephen T. |
Keywords: | Cell adhesion molecules Asthma Integrins Eosinophils |
Issue Date: | 1996 |
Publisher: | ERS |
Citation: | Peroni, D., Djukanovic, R., Bradding, P., Feather, I., Montefort, S., Howarth, P.,...Holgate, S. (1996). Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects. The European Respiratory Journal, 9(11), 2236-2242. |
Abstract: | We have investigated the expression of cell surface markers and leucocyte cell adhesion molecules by immunohistochemistry in bronchial biopsies from 10 mild atopic asthmatics and 8 normal, nonatopic subjects. Significantly increased numbers of eosinophils (p<0.01) were evident in the bronchial submucosa of asthmatic subjects. In epithelium there were more CD44+ (p<0.02) and lymphocyte function-associated antigen-1 (LFA-1)+ (p<0.06) leucocytes in asthmatics than in normal subjects. Bronchial epithelial cells stained positively with anti-CD44 monoclonal antibodies (moAb) in both groups; however, when the staining was expressed as percentage of the total basement membrane, a considerable and highly significant increase was observed in the asthmatics (median 80 vs 22%, p=0.003). Few leucocytes were positive for very late activation antigen (VLA)-1, VLA-2 and VLA-4. The moAb for VLA-6 stained the basement membrane of the bronchial epithelium; while intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were constitutively expressed in endothelium. A positive correlation was found between LFA-1+ cells and activated eosinophils (EG2+) in the submucosa (p<0.005; r(s)=0.80). We conclude that even in mild asthma there is evidence of increased expression of cell surface ligands, and suggest that adhesive mechanisms play a role both in cell recruitment and disease activity. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/23180 |
Appears in Collections: | Scholarly Works - FacM&SMed |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Expression of CD44 and integrins in bronchial mucosa__.pdf | 202.82 kB | Adobe PDF | View/Open |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.