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DC Field | Value | Language |
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dc.contributor.author | Gerretsen, Philip | - |
dc.contributor.author | Graff-Guerrero, Ariel | - |
dc.contributor.author | Menon, Mahesh | - |
dc.contributor.author | Pollock, Bruce G. | - |
dc.contributor.author | Kapur, Shitij | - |
dc.contributor.author | Vasdev, Neil | - |
dc.contributor.author | Houle, Sylvain | - |
dc.contributor.author | Mamo, David | - |
dc.date.accessioned | 2017-11-09T12:58:25Z | - |
dc.date.available | 2017-11-09T12:58:25Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Gerretsen, P., Graff-Guerrero, A., Menon, M., Pollock, B. G., Kapur, S., Vasdev, N., ... & Mamo, D. (2010). Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [18F] setoperone PET study. Social Neuroscience, 5(4), 375-383. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/23615 | - |
dc.description.abstract | Social behavior and desire for social relationships have been independently linked to the serotonergic system, the prefrontal cortex, especially the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). The goal of this study was to explore the role of serotonin 5HT2A receptors in these brain regions in forming and maintaining close interpersonal relationships. Twenty-four healthy subjects completed the Temperament and Character Inventory (TCI) prior to undergoing [18F]setoperone brain positron emission tomography (PET) to measure serotonin 5HT2A receptor availability within the OFC (BA 11 and 47) and ACC (BA 32). We explored the relationship between desire for social relationships, as measured by the TCI reward dependence (RD) scale, and 5HT2A receptor non-displaceable binding potential (BPnd) in these regions. Scores of RD were negatively correlated with 5HT2A BPnd in the ACC (BA 32, r = –.528, p = .012) and OFC (BA 11, r = –.489, p = .021; BA 47, r = –.501, p = .017). These correlations were corroborated by a voxel-wise analysis. These results suggest that the serotonergic system may have a regulatory effect on the OFC and ACC for establishing and maintaining social relationships. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Routledge | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Interpersonal relations | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | Tomography, Emission | en_GB |
dc.title | Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [18F] setoperone PET study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1080/17470911003589309 | - |
dc.publication.title | Social Neuroscience | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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File | Description | Size | Format | |
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Gerretsenetal2010SocNeurosci.pdf | 184.8 kB | Adobe PDF | View/Open |
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