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DC Field | Value | Language |
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dc.contributor.author | Ismail, Zahinoor | - |
dc.contributor.author | Nguyen, Minh-Quan | - |
dc.contributor.author | Fischer, Corinne E. | - |
dc.contributor.author | Schweizer, Tom A. | - |
dc.contributor.author | Mulsant, Benoit H. | - |
dc.contributor.author | Mamo, David | - |
dc.date.accessioned | 2017-11-09T13:33:14Z | - |
dc.date.available | 2017-11-09T13:33:14Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Ismail, Z., Nguyen, M. Q., Fischer, C. E., Schweizer, T. A., Mulsant, B. H., & Mamo, D. (2011). Neurobiology of delusions in Alzheimer’s disease. Current Psychiatry Reports, 13(3), 211-218. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/23643 | - |
dc.description.abstract | Alzheimer’s disease (AD) is associated with cognitive and functional impairment as well as neuropsychiatric sequelae, including psychotic symptoms such as delusions and hallucinations. Strong evidence supports the need to study delusions separate from hallucinations. Integrating the epidemiology, clinical correlates, and neuropathological and genetic literature for delusions in AD allows us to speculate on etiology and mechanisms. Plaque and tangle deposition in individuals with susceptible alleles of serotonergic, muscarinic, nicotinic, or Apoε4 genes appears to result in disruption of cortical circuitry, culminating in delusions. While delusions in AD correspond to a phenotype distinct from AD without delusions, subtypes of delusions may also define further distinct clinical entities. Persecutory delusions may occur earlier in the illness and have a more significant genetic component than misidentification delusions, which are associated with increased cognitive impairment and advanced dementia. Clearly distinguishing between these two syndromes is essential to making progress in the area of delusions in AD. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Springer Healthcare | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Alzheimer's disease | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | Dementia -- Patients -- Care | en_GB |
dc.subject | Dopamine | en_GB |
dc.subject | Psychoses | en_GB |
dc.subject | Delusions | en_GB |
dc.subject | Neuropsychiatry | en_GB |
dc.subject | Nervous system -- Diseases | en_GB |
dc.subject | Cognition -- Data processing | en_GB |
dc.title | Neurobiology of delusions in Alzheimer’s disease | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/s11920-011-0195-1 | - |
dc.publication.title | Current Psychiatry Reports | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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File | Description | Size | Format | |
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Ismail2011NeurobiologyDelusionsDementiaCurrPsychRep.pdf | 141.34 kB | Adobe PDF | View/Open |
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