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Title: Genetic and serological markers in identifying unclassified colitis
Authors: Fenech, Valerie Anne
Schembri, John
Ellul, Pierre
Grech, Godfrey
Azzopardi, Neville
Keywords: Inflammatory bowel diseases
Crohn’s disease
Ulcerative colitis
Issue Date: 2016
Publisher: InTech
Citation: Fenech, V. A., Schembri, J., Ellul, P., Grech, G., & Azzopardi, N. (2016). Genetic and serological markers in identifying unclassified colitis. In New Insights into Inflammatory Bowel Disease. In S. Huber (Ed.), New Insights into Inflammatory Bowel Disease (pp. 51-67). InTech.
Abstract: In 5–15% of the patients with inflammatory bowel disease (IBD) limited to the colon, it is difficult to distinguish histologically between ulcerative and Crohn’s colitis. This is described as unclassified colitis. Distinguishing between the two is important in terms of prognosis, since patients with Crohn’s disease (CD) have a higher risk of strictures and fistulae, which may predict a more severe disease course, as well as an increased risk for surgery. In addition, colectomy may be curative in ulcerative colitis patients not responding to medical therapy, while Crohn’s patients undergoing colectomy can have relapses in other areas of the bowel and, therefore, need to be followed-up. In inflammatory bowel disease, intestinal inflammation is believed to occur secondary to an altered immune response in a genetically susceptible host. Genetic and serological markers (antibodies) may have a role in identifying unclassified colitis. Anti-Saccharomyces cerevisiae antibody (ASCA) and anti-neutrophil cytoplasmic antibodies (pANCA) have the highest sensitivity in distinguishing ulcerative from Crohn’s colitis. Nucleotide oligomerization domain 2 (NOD2) and autophagy-related 16-like 1 (ATG16L1) polymorphisms are strongly associated with Crohn’s disease, while epithelial barrier genes are significantly associated with ulcerative colitis. This chapter describes which gene polymorphisms and serological markers may be used to distinguish between ulcerative colitis and Crohn’s disease in patients with histologically unclassified colitis.
Description: Acknowledgements- Contribution: Valerie A. Fenech and John Schembri contributed equally to research the data and write the paper. Pierre Ellul, Godfrey Grech, and Neville Azzopardi reviewed the paper and were also involved in writing the manuscript.
ISBN: 9789535127550
Appears in Collections:Scholarly Works - FacM&SMed
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