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dc.contributor.authorCrunelli, Vincenzo-
dc.contributor.authorLorincz, Magor L.-
dc.contributor.authorFurdan, Szabina-
dc.contributor.authorOrban, Gergely-
dc.contributor.authorColangeli, Roberto-
dc.contributor.authorDelicata, Francis-
dc.contributor.authorDeidda, Gabrielle-
dc.contributor.authorAttard Trevisan, Adrian-
dc.contributor.authorPierucci, Massimo-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.identifier.citationCrunelli, V., Lorincz, M. L., Furdan, S., Orban, G., Colangeli, R., Delicata, F., ... Di Giovanni, G. (2017). Targeting the Serotonin (5-HT) system to control seizures. Xjenza, 5(1), 3-14.en_GB
dc.description.abstractCompelling animal and human evidence suggests that serotonin plays an important role in the pathophysiology of epilepsy as it is involved in iperexcitability, epileptogenesis, seizure generation, depression and psychiatric disorders comorbid with epilepsy. Serotonin involvement in epilepsy is complex; the reasons are twofold i) epilepsy is in reality a spectrum disorder, and ii) serotonin effects vary from one form of epilepsy to another, due also to the different serotonin receptors involved. Here, we will focus on the role of serotonin and its 5-HT2 receptors in absence epilepsy. Our recent pharmacological experimental evidence in GAERS will be reviewed together with our preliminary optogenetic results. 5-HT2C receptor agonists may represent a new approach to interfere with seizure generation and seizure management. Our optogenetic experiments also indicate that by modulating rhythmic cortical activity, optogenetic stimulation of the serotonergic system may provide seizure control without the adverse effects induced by pharmacological activation of 5-HT2C receptors. Thus, targeting the serotonergic system could provide novel insights into the pathophysiological mechanisms of seizure generation and lead to potentially novel treatments.en_GB
dc.publisherMalta Chamber of Scientistsen_GB
dc.subjectSerotonin -- Receptorsen_GB
dc.subjectEpilepsy -- Etiologyen_GB
dc.subjectEpilepsy -- Treatmenten_GB
dc.titleTargeting the Serotonin (5-HT) system to control seizuresen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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Xjenza, 2017, Volume 5, Issue 1
Xjenza, 2017, Volume 5, Issue 1

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