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Title: The role of translation initiation regulation in haematopoiesis
Authors: Grech, Godfrey
Lindern, Marieke von
Keywords: Hematopoietic stem cells
Gene expression
Issue Date: 2012
Publisher: Hindawi
Citation: Grech, G., & Von Lindern, M. (2012). The role of translation initiation regulation in haematopoiesis. Comparative and Functional Genomics, 1-9.
Abstract: Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors. Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression. This paper outlines how these posttranscriptional control mechanisms, including control at the level of translation initiation factors and the role of RNA binding proteins, affect hematopoiesis. The clinical relevance of these mechanisms in haematological disorders indicates clearly the potential therapeutic implications and the need of molecular tools that allowmeasurement at the level of translational control. Although the importance of miRNAs in translation control is well recognised and studied extensively, this paper will exclude detailed account of this level of control.
Appears in Collections:Scholarly Works - FacM&SPat

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