Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/25648
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dc.contributor.authorAzzopardi, Neville-
dc.contributor.authorEllul, Pierre-
dc.contributor.authorSaliba, Christian-
dc.contributor.authorCalleja, Neville-
dc.contributor.authorLaFerla, Godfrey-
dc.contributor.authorGrech, Godfrey-
dc.date.accessioned2018-01-10T08:52:42Z-
dc.date.available2018-01-10T08:52:42Z-
dc.date.issued2017-
dc.identifier.citationAzzopardi, N., Ellul, P., Saliba, C., Calleja, N., LaFerla, G., & Grech, G. (2017). Thr300Ala ATG16L1 polymorphisms and bone strength in Crohn’s disease patients. Malta Medical Journal, 29(3), 15-24.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/25648-
dc.description.abstractIntroduction: Studies on the effect of deletion of ATG5 and ATG7 proteins on bone cell function and bone strength in laboratory mice have revealed an association between autophagy and osteoporosis. The effect on bone strength of the Thr300Ala variant (rs2241880 polymorphism) of the ATG16l1 gene, a Crohn’s disease susceptibility gene essential in macroautophagy, has not yet been explored. Methods: 101 Crohn’s disease patients underwent DEXA bone density scanning. Real time PCR, high resolution melt (HRM) and restriction fragment length polymorphism (RFLP) were made use of as to assess for the rs2241880 polymorphism of the ATG16L1 gene in these patients. Results: HRM and RFLP demonstrated that 39.6% had the wild type rs2241880 (Thr300Ala) polymorphism while 7.9% were homozygous and 52.5% were heterozygous for the polymorphism. Mean DEXA bone mineral density scores in these patients showed lower T scores at the hip (1.74) among patients with the homozygous polymorphism than among patients with the heterozygous polymorphism (mean T score hip: -1.29). The highest mean T scores were found in patients with the wild type polymorphism (-1.04). Discussion: This study demonstrates the first evidence that polymorphisms in the ATG16L1 gene may play a role in bone metabolism.en_GB
dc.language.isoenen_GB
dc.publisherUniversity of Malta. Medical Schoolen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectOsteoporosis -- Maltaen_GB
dc.subjectCrohn's disease -- Patientsen_GB
dc.subjectBones -- Diseasesen_GB
dc.subjectCrohn's disease -- Etiologyen_GB
dc.titleThr300Ala ATG16L1 polymorphisms and bone strength in Crohn’s disease patientsen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.publication.titleMalta Medical Journalen_GB
Appears in Collections:MMJ, Volume 29, Issue 3
MMJ, Volume 29, Issue 3
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