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DC Field | Value | Language |
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dc.contributor.author | Gerretsen, Philip | - |
dc.contributor.author | Graff-Guerrero, Ariel | - |
dc.contributor.author | Mamo, David | - |
dc.contributor.author | Pollock, Bruce G. | - |
dc.contributor.author | Menon, Mahesh | - |
dc.date.accessioned | 2018-02-14T08:38:08Z | - |
dc.date.available | 2018-02-14T08:38:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Gerretsen, P., Graff-Guerrero, A., Mamo, D., Pollock, B. G., Menon, M. (2012). Delineating the functional neuroanatomy of illness denial or anosognosia in schizophrenia. 3rd Biennial Schizophrenia International Research Society (SIRS) Conference, Florence. 100-101. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/26702 | - |
dc.description.abstract | The constructs of illness denial and anosognosia (lack of illness awareness) represent two sides of the same coin. The former implies an active psychological process whereas the latter suggests a neurological deficit. Although the neural mechanisms of illness denial are not understood, its counterpart anosognosia is commonly associated with right hemispheric damage secondary to stroke, neurodegeneration or brain injury. In cases of anosognosia secondary to stroke, patients are not only unaware of their condition, but when confronted with their deficits they deny their hemiparesis, confabulate, and may experience so- matoparaphrenia – the delusional attribution of the paralyzed limb to someone else, such as the doctor, nurse or family member. Schizophrenia spectrum disorders are characterized by gross misperceptions of reality, hallucinations and bizarre delusions in combination with anosognosia and denial of need for treatment, which contributes significantly to the ill- ness’ morbidity. This population, in which illness denial is a characteristic feature of the disorder, provides an extraordinary opportunity to explore the functional neuroanatomy of this phenomenon. In accordance with the literature demonstrating a relationship between lack of illness awareness and right hemisphere lesions, anosognosia in schizophrenia is associated with volumetric reductions within right frontal regions, specifically the OFC, dlPFC, and anterior cingulate cortices, and also the right parietal lobe in studies that used a region of interest approach. A recent hemisphere asymmetry analysis by our group found anosognosia was associated with relatively reduced right frontotemporoparietal volume. Based on these findings, we hypothesized denial of illness would be associated with left hemisphere activation in the mPFC, dlPFC and temporoparietaoccipital junction (TPO). | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Schizophrenia International Research Society | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Anosognosia | en_GB |
dc.subject | Cognitive psychology | en_GB |
dc.subject | Schizophrenia | en_GB |
dc.title | Delineating the functional neuroanatomy of illness denial or anosognosia in schizophrenia | en_GB |
dc.type | conferenceObject | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.bibliographicCitation.conferencename | 3rd Biennial Schizophrenia International Research Society (SIRS) Conference | en_GB |
dc.bibliographicCitation.conferenceplace | Florence, Italy, 14-18/04/2012 | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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