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dc.contributor.authorLaureys, Guy-
dc.contributor.authorValentino, Mario-
dc.contributor.authorDemol, Frauke-
dc.contributor.authorZammit, Christian-
dc.contributor.authorMuscat, Richard-
dc.contributor.authorCambron, Melissa-
dc.contributor.authorKooijman, Ron-
dc.contributor.authorKeyser, Jacques De-
dc.date.accessioned2018-02-14T09:15:21Z-
dc.date.available2018-02-14T09:15:21Z-
dc.date.issued2014-
dc.identifier.citationLaureys, G., Valentino, M., Demol, F., Zammit, C., Muscat, R., Cambron, M., ... & De Keyser, J. (2014). β2-adrenergic receptors protect axons during energetic stress but do not influence basal glio-axonal lactate shuttling in mouse white matter. Neuroscience, 277, 367-374.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/26718-
dc.description.abstractIn vitro studies have demonstrated that b2-adrenergic receptor activation stimulates glycogen degradation in astrocytes, generating lactate as a potential energy source for neurons. Using in vivo microdialysis in mouse cerebellar white matter we demonstrate continuous axonal lactate uptake and glial–axonal metabolic coupling of glutamate/ lactate exchange. However, this physiological lactate production was not influenced by activation (clenbuterol) or blocking (ICI 118551) of b2-adrenergic receptors. In two-photon imaging experiments on ex vivo mouse corpus callosum subjected to aglycemia, b2-adrenergic activation rescued axons, whereas inhibition of axonal lactate uptake by a-cyano-4-hydroxycinnamic acid (4-CIN) was associated with severe axonal loss. Our results suggest that axonal protective effects of glial b2-adrenergic receptor activation are not mediated by enhanced lactate production.en_GB
dc.language.isoenen_GB
dc.publisherPergamon Pressen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectGlucoseen_GB
dc.subjectAdrenergic beta agonists in animal nutritionen_GB
dc.subjectAdrenergic beta blockers -- Physiological effecten_GB
dc.subjectLactic aciden_GB
dc.subjectBeta adrenoceptorsen_GB
dc.subjectGlutamic aciden_GB
dc.subjectAxons -- Physiologyen_GB
dc.titleβ2-adrenergic receptors protect axons during energetic stress but do not influence basal glio-axonal lactate shuttling in mouse white matteren_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/j.neuroscience.2014.07.022-
dc.publication.titleNeuroscienceen_GB
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