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dc.contributor.authorBalzan, Martin-
dc.contributor.authorBilocca, David-
dc.contributor.authorZammit, Christopher-
dc.contributor.authorCibella, Fabio-
dc.contributor.authorColombo, Paolo-
dc.contributor.authorLongo, Valeria-
dc.contributor.authorBorg, Charles-
dc.contributor.authorPiva, Giuseppe-
dc.contributor.authorMontefort, Stephen-
dc.contributor.authorViegi, Giovanni-
dc.identifier.citationBalzan, M., Bilocca, D., Zammit, C., Cibella, F., Colombo, P., Longo, V.,… Viegi, G. (2014). Total serum IgE and specific IgE levels in 10-15 year old children with respiratory symptoms and healthy controls in Sicily and Malta. European Respiratory Journal, 44(58), 4029.en_GB
dc.description.abstractIntroduction: The RESPIRA study (EU Funded-Italia-Malta) was performed in the district of Gela (Southern Sicily) and Malta in 2012/3 in 10-15 years old schoolchildren (n=2,047) by means of standard respiratory questionnaires (ISAAC),and clinical exam of case and control subjects. Aims and Objectives: To measure total serum IgE levels in cases (n=127, males=45) and controls (n=142, Males=64), specific IgEs in cases (n=90, Males=53), and controls (n=82, Males=38). Materials and Methods: Cases reported wheeze and/or use of asthma medications in the last 12 months, while controls answered negatively to both and rhinitis. Results: Total Serum IgE (n=269) was raised (>144 IU/l) in 70/127 cases vs 25/142 controls (p=.0001). In males 30/76 of cases vs 11/64 controls (p=.005), while in females cases 15/51 vs 14/78, (p=.14). Positive specific IgE (>0.34 U/ml) was noted for at least one allergen in 54/90 cases vs 30/82 controls (p=.002). House dust mite (HDM) was positive in 27/90 cases vs 12/82 controls (p=.0001), Parietaria positive 12/90 cases vs 2/82 controls (p=.011), cat 22/90 vs 13/82 controls (p=.19), while in male subgroup 14/53 of cases were positive vs 4/38 controls (p=.06). Dog 9/90 cases vs 8/82 controls (NS). Olive positive in 13/90 cases vs 8/82 controls (NS). Alternaria positive in 6/90 cases vs 2/82 controls (NS). Goldenrod Solidago Virgaurea positive in 2/90 cases vs 1/82 controls, and Cladosporium 0/90 cases, 1/82 controls. Conclusion: Positive Total serum IgE and specific IgE to HDM and Parietaria in all patients and cat in males only were higher in cases than in controls.en_GB
dc.publisherEuropean Respiratory Societyen_GB
dc.subjectAsthma -- Maltaen_GB
dc.subjectAsthma -- Italy -- Sicilyen_GB
dc.subjectImmunoglobulin Een_GB
dc.subjectAsthma in childrenen_GB
dc.titleTotal serum IgE and specific IgE levels in 10-15 year old children with respiratory symptoms and healthy controls in Sicily and Maltaen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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