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DC Field | Value | Language |
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dc.contributor.author | Scerri, Charles | - |
dc.date.accessioned | 2018-03-06T17:25:29Z | - |
dc.date.available | 2018-03-06T17:25:29Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Scerri, C. (2009). Differential effects of age on tau protein expression in the rat brain following chronic nicotine administration in vivo. Alzheimer's & Dementia, 5(4), 431. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/27743 | - |
dc.description.abstract | Alzheimer's disease (AD) is the most common form of dementia in the elderly. Its pathology is characterised by the presence of intracellular neurofibrillary tangles made up of abnormally phosphorylated forms of microtubule-associated protein tau and deposition of the insoluble β-amyloid protein derived from the enzymatic cleavage of the amyloid precursor protein. Neuronal degeneration with impaired cholinergic transmission is also present, particularly in areas of the cerebral cortex and hippocampus. Several studies indicate that stimulation of central nicotinic acetylcholine receptors by nicotine is effective in attenuating the cognitive deficits observed in AD. The aim of this study was to investigate the effects of chronic nicotine administration on tau expression in the cerebral cortex, striatum and hippocampus of young and old rat brain. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Inc. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Rats as laboratory animals | en_GB |
dc.subject | Nicotine | en_GB |
dc.subject | Tau proteins | en_GB |
dc.title | Differential effects of age on tau protein expression in the rat brain following chronic nicotine administration in vivo | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.jalz.2009.04.972 | - |
dc.publication.title | Alzheimer's & Dementia | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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