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dc.contributor.authorFrisoni, Giovanni B.-
dc.contributor.authorBoccardi, Marina-
dc.contributor.authorBarkhof, Frederik-
dc.contributor.authorBlennow, Kaj-
dc.contributor.authorCappa, Stefano-
dc.contributor.authorChiotis, Konstantinos-
dc.contributor.authorDemonet, Jean-Francois-
dc.contributor.authorGaribotto, Valentina-
dc.contributor.authorGiannakopoulos, Panteleimon-
dc.contributor.authorGietl, Anton-
dc.contributor.authorHansson, Oskar-
dc.contributor.authorHerholz, Karl-
dc.contributor.authorJack, Clifford R.-
dc.contributor.authorNobili, Flavio-
dc.contributor.authorNordberg, Agneta-
dc.contributor.authorSnyder, Heather M.-
dc.contributor.authorKate, Mara Ten-
dc.contributor.authorVarrone, Andrea-
dc.contributor.authorAlbanese, Emiliano-
dc.contributor.authorBecker, Stefanie-
dc.contributor.authorBossuyt, Patrick-
dc.contributor.authorCarrillo, Maria C.-
dc.contributor.authorCerami, Chiara-
dc.contributor.authorDubois, Bruno-
dc.contributor.authorGallo, Valentina-
dc.contributor.authorGiacobini, Ezio-
dc.contributor.authorGold, Gabriel-
dc.contributor.authorHurst, Samia-
dc.contributor.authorLonneborg, Anders-
dc.contributor.authorLovblad, Karl-Olof-
dc.contributor.authorMattsson, Niklas-
dc.contributor.authorMolinuevo, Jose-Luis-
dc.contributor.authorMonsch, Andreas U.-
dc.contributor.authorMosimann, Urs-
dc.contributor.authorPadovani, Alessandro-
dc.contributor.authorPicco, Agnese-
dc.contributor.authorPorteri, Corinna-
dc.contributor.authorRatib, Osman-
dc.contributor.authorSaint-Aubert, Laure-
dc.contributor.authorScerri, Charles-
dc.contributor.authorScheltens, Philip-
dc.contributor.authorSchott, Jonathan M.-
dc.contributor.authorSonni, Ida-
dc.contributor.authorTeipel, Stefan-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorVisser, Pieter Jelle-
dc.contributor.authorYasui, Yutaka-
dc.contributor.authorWinblad, Bengt-
dc.identifier.citationFrisoni, G. B., Boccardi, M., Barkhof, F., Blennow, K., Cappa, S., Chiotis, K.,… Winblad, B. (2017). Strategic roadmap for an early diagnosis of Alzheimer’s disease based on biomarkers. The Lancet Neurology, 16(8), 661-676.en_GB
dc.description.abstractThe diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness of these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insurance providers, their widespread clinical implementation, and improvements in quality of health care. We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers. Sufficient evidence of analytical validity (phase 1 of a structured framework adapted from oncology) is available for all biomarkers, but their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete. To complete these phases, research priorities include the standardisation of the readout of these assays and thresholds for normality, the evaluation of their performance in detecting early disease, the development of diagnostic algorithms comprising combinations of biomarkers, and the development of clinical guidelines for the use of biomarkers in qualified memory clinics.en_GB
dc.publisherThe Lancet Publishing Groupen_GB
dc.subjectAlzheimer's diseaseen_GB
dc.subjectEarly diagnosisen_GB
dc.subjectValidation studies as topicen_GB
dc.subjectTomography, Emissionen_GB
dc.subjectCerebrospinal fluid proteinsen_GB
dc.titleStrategic roadmap for an early diagnosis of Alzheimer’s disease based on biomarkersen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleThe Lancet Neurologyen_GB
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